Nocturnal Hypoxemia and Severe Obstructive Sleep Apnea are Associated with Incident Type 2 Diabetes in a Population Cohort of Men

Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine
Sarah L AppletonRobert J Adams

Abstract

Studies examining the longitudinal association of untreated obstructive sleep apnea (OSA) with diabetes in population samples are limited. This study therefore examined the relationship between previously undiagnosed OSA with incident type 2 diabetes in community-dwelling men aged ≥ 40 y. The Men Androgen Inflammation Lifestyle Environment and Stress (MAILES) Study is a longitudinal population-based cohort in Adelaide, South Australia. Clinic assessments at baseline and follow-up identified diabetes (self-reported doctor diagnosed, fasting plasma glucose ≥ 7.0 mmol/L, glycated hemoglobin ≥ 6.5% or diabetes medication use) and included anthropometry. At cohort follow-up (2010-2012), n = 837 underwent full in-home unattended polysomnography (PSG, Embletta X100, Broomfield, CO). Of 736 men free of diabetes at baseline, incident diabetes occurred in 66 (9.0%) over a mean follow-up time of 56 mo (standard deviation = 5, range: 48-74 mo). Incident diabetes was associated with current oxygen desaturation index (3%) ≥ 16 events/h (odds ratio [OR]: 1.85 [1.06-3.21]), and severe OSA [OR: 2.6 (1.1-6.1)], in adjusted models including age, percentage total body fat, and weight gain (> 5 cm waist circumference). An age-adjusted association o...Continue Reading

Citations

Feb 22, 2016·The American Journal of the Medical Sciences·Peilin HuiShuhong Zhou
Jul 1, 2016·The Journal of Physiology·Craig L PhillipsRonald R Grunstein
Jun 8, 2017·Respirology : Official Journal of the Asian Pacific Society of Respirology·Carol J LangRobert J Adams
May 22, 2017·Chest·Sirimon Reutrakul, Babak Mokhlesi
Jul 12, 2018·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Imre Hunyor, Kristina M Cook
Jun 18, 2016·Respirology : Official Journal of the Asian Pacific Society of Respirology·Robert J AdamsGary A Wittert
May 17, 2017·European Journal of Applied Physiology·Tomoyuki Kawada
Mar 15, 2018·Frontiers in Surgery·David StevensAndrew Vakulin
Aug 22, 2018·Frontiers in Endocrinology·Sarah N Framnes, Deanna M Arble
Aug 29, 2019·International Journal of Environmental Research and Public Health·Hiroshi KimuraShin Takasawa
Sep 9, 2017·Sleep & Breathing = Schlaf & Atmung·Xiaoxia LuTaoping Li
Jul 18, 2019·Multidisciplinary Respiratory Medicine·Marta Marin-OtoJose M Marin
Jun 22, 2021·Sleep Medicine·R Nisha Aurora, Naresh M Punjabi

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