Nocturnal melatonin levels are unaltered by ovarian suppression in girls with central precocious puberty

Fertility and Sterility
S L BergaS S Yen

Abstract

Girls with central precocious puberty were utilized as a model in which to study the melatonin secretory response to ovarian suppression. Eight girls with central precocious puberty documented by clinical and endocrine characteristics, including sleep-entrained augmentation of luteinizing hormone (LH) pulsatility, were investigated. Nocturnal (6:00 P.M. to 9:00 A.M.) plasma melatonin levels were measured hourly by a sensitive and specific radioimmunoassay before and after gonadotropin-ovarian downregulation with gonadotropin-releasing hormone (GnRH)-agonist. Although nocturnal melatonin elevations varied widely between girls, patterns within the same individual were remarkably reproducible and unaltered before and after treatment. Although estrogens have been shown to modulate melatonin synthesis and secretion, in this model, reduction of estrogen levels was not associated with alterations in plasma melatonin concentrations.

Citations

Jun 1, 1996·Journal of Endocrinological Investigation·A Cagnacci, A Volpe
Feb 1, 1997·Psychiatry and Clinical Neurosciences·S MadokoroK Isaki
Apr 1, 1997·Journal of Pineal Research·R M WhiteR F Seamark
Jul 21, 2010·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Felisbela Soares de HolandaJosé Maria Soares
Sep 29, 2011·Developmental Psychobiology·Stephanie J CrowleyMary A Carskadon
Oct 1, 1993·Journal of Pineal Research·A Cavallo
Oct 1, 1995·Journal of Pediatric Endocrinology & Metabolism : JPEM·R LuboshitzkyA Etzioni
Jul 17, 1998·Clinical Endocrinology·M Ozata, Z Beyhan

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