Nocturnal Melatonin Suppression by Adolescents and Adults for Different Levels, Spectra, and Durations of Light Exposure

Journal of Biological Rhythms
R NagareMariana G Figueiro

Abstract

The human circadian system is primarily regulated by the 24-h LD cycle incident on the retina, and nocturnal melatonin suppression is a primary outcome measure for characterizing the biological clock's response to those light exposures. A limited amount of data related to the combined effects of light level, spectrum, and exposure duration on nocturnal melatonin suppression has impeded the development of circadian-effective lighting recommendations and light-treatment methods. The study's primary goal was to measure nocturnal melatonin suppression for a wide range of light levels (40 to 1000 lux), 2 white light spectra (2700 K and 6500 K), and an extended range of nighttime light exposure durations (0.5 to 3.0 h). The study's second purpose was to examine whether differences existed between adolescents' and adults' circadian sensitivity to these lighting characteristics. The third purpose was to provide an estimate of the absolute threshold for the impact of light on acute melatonin suppression. Eighteen adolescents (age range, 13 to 18 years) and 23 adults (age range, 24 to 55 years) participated in the study. Results showed significant main effects of light level, spectrum, and exposure duration on melatonin suppression. More...Continue Reading

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Citations

Jun 17, 2020·Journal of Biological Rhythms·Martin Moore-EdeRainer Guttkuhn
Oct 23, 2020·Clocks & Sleep·Mirjam MünchDebra J Skene
Feb 10, 2021·Clocks & Sleep·Mirjam MünchDebra J Skene
Feb 23, 2021·Frontiers in Neuroscience·Mark S ReaMariana G Figueiro
Feb 23, 2021·Frontiers in Neuroscience·Mark S ReaMariana G Figueiro
Jul 22, 2021·Neurobiology of Sleep and Circadian Rhythms·Rohan NagareMariana G Figueiro
Oct 18, 2021·The FEBS Journal·Qingqing Lu, Jin Young Kim
Jan 31, 2020·Journal of Environmental Management·Joseph CaruanaNoel J Aquilina

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Software Mentioned

Daysimeter
SPSS
Matlab

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