Nocturnal penile tumescence and rigidity evaluation in men with epilepsy

Epilepsia
G T Guldner, M J Morrell

Abstract

Men with epilepsy appear to have an approximately fivefold increase in risk of erectile dysfunction (ED). We attempted to determine whether ED in men with epilepsy was due to a physiological basis and whether erectile function could be adequately evaluated with an ambulatory nocturnal penile tumescence and rigidity monitor. The physiologic integrity of the sexual response in men with epilepsy and ED was assessed with an ambulatory nocturnal penile tumescence and rigidity monitor (NPTR). Six men with localization-related epilepsy of temporal lobe origin (TLE) and ED, 2 men with TLE and normal sexual function, and 1 man with nonepileptic seizures (NES) and ED underwent evaluation of nocturnal erections for at least 2 nights. Five of 6 men with TLE and complaints of ED had abnormal ambulatory NPTR evaluations. All others had normal ambulatory NPTR. All abnormal evaluations showed reduced levels of rigidity, often with normal levels of tumescence. Previous studies have shown this abnormal ambulatory NPTR pattern to be associated with neurogenic rather than vasogenic ED. Therefore, epilepsy-related ED may have a substantial neurophysiologic component.

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Citations

Sep 7, 2000·Neuroscience and Biobehavioral Reviews·H E EdwardsW M Burnham
Mar 1, 2003·Epilepsy & Behavior : E&B·Cynthia L. Harden
Oct 29, 2005·International Journal of Impotence Research·S HamedH Omar
Jun 26, 2001·Epilepsia·F M Besag
Jun 26, 2003·Epilepsia·Martha J Morrell
May 13, 1998·Epilepsia·D M FeeneyW Gilmore
Oct 13, 2012·The Journal of Sexual Medicine·Rosana Maria ReisLúcia Alves Silva Lara
May 23, 2012·The Journal of Sexual Medicine·Gabriela MatosMonica L Andersen
Jun 14, 2001·The Urologic Clinics of North America·A Nehra, R B Moreland
Aug 8, 2001·Seizure : the Journal of the British Epilepsy Association·M V Lambert
Dec 29, 2007·Seizure : the Journal of the British Epilepsy Association·Eva Hellmis
Aug 25, 2004·Seizure : the Journal of the British Epilepsy Association·M SmaldoneA Khan
Jan 26, 2005·Urology·Marie NorredamMichael Grodin
Dec 17, 2008·Physical Medicine and Rehabilitation Clinics of North America·James Kennedy

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