Nocturnal wrist movements are correlated with objective clinical scores and plasma chemokine levels in children with atopic dermatitis

The British Journal of Dermatology
K-L E HonP-C Ng

Abstract

Atopic dermatitis (AD) is a distressing disease associated with pruritus and sleep disturbance. Scratching due to pruritus is an important mechanism in the exacerbation of AD but is difficult to document in the home environment. To evaluate whether nocturnal wrist activities, defined as average acceleration in the early hours of sleep, were correlated with components of the SCORing Atopic Dermatitis (SCORAD) index and various AD-associated chemokine markers. Patients with AD aged under 18 years were recruited and the severity of eczema was assessed with the SCORAD index. Concentrations of plasma AD-associated chemokines [cutaneous T-cell attracting cytokine (CTACK); macrophage-derived chemokine (MDC); thymus and activation regulated chemokine (TARC)], interleukin (IL)-18, serum total IgE, and eosinophil counts were measured in these patients. Healthy children with noninflammatory and nonitchy skin conditions as well as healthy children of staff volunteers were recruited as controls. All children were instructed to wear the DigiTrac monitor on their dominant wrist before sleeping. The monitor was programmed to record limb motion between 22.00 and 08.00 h the following morning. Twenty-four Chinese children with AD (mean +/- SD ag...Continue Reading

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Citations

Jul 11, 2006·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·K L E HonP C Ng
Sep 14, 2007·The Journal of Dermatological Treatment·Kam-Lun Ellis HonAlexander K C Leung
Apr 16, 2010·Sleep Medicine Reviews·Danny CamffermanKurt Lushington
May 8, 2007·Journal of Neuroscience Methods·Sridhar SunderamBruce J Gluckman
Sep 12, 2006·Veterinary Dermatology·Tim Nuttall, Neil McEwan
Jan 5, 2008·International Journal of Dermatology·Kam-Lun Ellis HonNai-Ming Luk
Aug 7, 2008·Clinical and Experimental Dermatology·K L E HonP C Ng
May 5, 2011·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Kam Lun HonTing Fan Leung
Feb 7, 2013·The British Journal of Dermatology·C Wootton, K Thomas
Apr 27, 2011·Journal of the European Academy of Dermatology and Venereology : JEADV·T F LeungK L Hon
Jun 6, 2009·Clinical and Experimental Dermatology·K L E HonP C Ng
Jun 20, 2012·IEEE Journal of Biomedical and Health Informatics·Johanna PetersenTamara L Hayes
Apr 5, 2016·International Journal of Molecular Sciences·Yung-Sen Chang, Bor-Luen Chiang
May 6, 2016·International Journal of Molecular Sciences·Harneet K Walia, Reena Mehra
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Mar 18, 2008·The British Journal of Dermatology·T F LeungK L E Hon
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Jul 1, 2019·Dermatology and Therapy·Mary Patricia SmithWilson Liao
Jun 21, 2020·Current Allergy and Asthma Reports·Rachel Shireen GolpanianGil Yosipovitch
Feb 21, 2018·The Journal of Dermatological Treatment·K L HonT F Leung
Mar 9, 2021·Frontiers in Medicine·Aylin RuppensteinUlrike Raap
Dec 16, 2020·The Journal of Allergy and Clinical Immunology. in Practice·Fatima BawanyWilfred R Pigeon
Oct 9, 2007·Advances in Pediatrics·Alexander K C LeungWm Lane M Robson

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Atopic dermatitis is a chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. Discover the latest research on atopic dermatitis here.

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