NOD bone marrow-derived dendritic cells are modulated by analogs of 1,25-dihydroxyvitamin D3

The Journal of Steroid Biochemistry and Molecular Biology
E van EttenC Mathieu

Abstract

The immune effects of 1,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)) are mainly mediated through dendritic cells (DCs). In vitro, 1,25(OH)(2)D(3) treatment renders murine bone marrow (BM)-derived DCs more tolerogenic, indirectly altering behavior and fate of T lymphocytes. In vivo, treatment with 1,25(OH)(2)D(3) or its analogs prevents diabetes in NOD mice. The aim of this study was to investigate the effects of the 1,25(OH)(2)D(3)-analog TX527 on the expression of antigen-presenting and costimulatory/migratory molecules on BM-derived DCs from NOD mice. After culture with 20 ng/ml GM-CSF + 20 ng/ml IL-4 (8 days) followed by 1000 ng/ml LPS + 100 U/ml IFN-gamma (2 days), with or without 10(-8)M TX527, cells were counted and analyzed by FACS for MHC II, CD86, CD40 and CD54 expression within the CD11c(+) DC population. Upon TX527 treatment, cell recovery was significantly reduced whereas the CD11c(+) DC fraction remained constant. On CD11c(+) DCs, MHC II, CD86 and CD54 were significantly down-regulated and CD40 was twofold upregulated. Globally, BM-derived DCs from NOD mice become more tolerogenic upon TX527 treatment, confirming the effects of 1,25(OH)(2)D(3) on murine DCs and possibly explaining the protective effects of 1,25(OH)(2...Continue Reading

Citations

Jun 23, 2005·Diabetologia·C MathieuR Bouillon
Jun 9, 2005·The Journal of Steroid Biochemistry and Molecular Biology·Rohan RajapakseErmanno Candolfi
Jun 22, 2012·The British Journal of Nutrition·Shalbha TiwariSurya Kumar Singh
Apr 17, 2014·International Orthopaedics·Gerrit Steffen MaierUwe Maus
Mar 10, 2009·Journal of Autoimmunity·Ruben Darío MotrichChantal Mathieu
Feb 9, 2005·Annals of the New York Academy of Sciences·Evelyne van EttenChantal Mathieu
Nov 10, 2011·Diabetes/metabolism Research and Reviews·Gabriela Bomfim FerreiraChantal Mathieu
Sep 8, 2011·Immunology·Michelino Di RosaLucia Malaguarnera
Aug 21, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Hadeel A Al-RawafAhmad H Alghadir
Mar 13, 2019·Nutrition & Diabetes·Jiezhi DaiYimin Chai
Jul 18, 2020·The Cochrane Database of Systematic Reviews·Zena Eh MooreDeclan Patton
Mar 26, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Gabriela B FerreiraChantal Mathieu
Aug 3, 2020·Plastic and Reconstructive Surgery·Rebecca KnackstedtJames Gatherwright
Jun 17, 2020·Plastic and Reconstructive Surgery·Rebecca KnackstedtJames Gatherwright

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