NOD2 is highly expressed in Behçet disease with pulmonary manifestations.

Journal of Inflammation
Kamel HamzaouiAgnès Hamzaoui

Abstract

Excessive Th1 cells and TLRs functions are involved in the pathogenesis of Behcet's disease (BD) in response to bacterial antigens. NOD2, an intracellular pathogen recognition sensor, modulates innate defence to muropeptides derived from various bacterial species. To further define a role for NOD2 in BD, we analysed NOD2 transcriptional responses in BAL-MNC from BD patients with pulmonary manifestations. We analysed NOD1, NOD2, T-bet and TLRs mRNA expression with real-time polymerase chain-reaction in BAL cells obtained from 23 BD patients with pulmonary manifestations and their matched controls. We found that NOD2 mRNA expression was highly up-regulated in BAL cells from BD and sarcoidosis patients compared to healthy control group (P = 0.001). In BD patients, significant correlation was found between NOD2 and T-bet mRNA expression (r = 0.602; P = 0.0009). In BAL from BD patients, NOD2 and T-bet mRNA expression were significantly correlated with BAL-lymphocytes (r = 0.485, P = 0.010; r = 0684, P = 0.0001 respectively). NOD2 in BD was also correlated with TLR 2(r = 0.444; P = 0.021) and TLR 4 (r = 0.574; P = 0.001) mRNA expression. Our results indicate that BAL-MNC from BD patients expressed NOD2 as a result of lung inflammatio...Continue Reading

References

Jul 2, 1998·Clinical and Experimental Immunology·S Hirohata, T Hashimoto
Feb 26, 2000·The New England Journal of Medicine·G E Ehrlich
Jul 27, 2000·Annals of the Rheumatic Diseases·A GülM Koniçe
Oct 9, 2002·Scandinavian Journal of Rheumatology·Kamel HamzaouiKhaled Ayed
Jan 7, 2003·The Journal of Biological Chemistry·Naohiro InoharaGabriel Nuñez
Jan 16, 2003·The Journal of Biological Chemistry·Stephen E GirardinPhilippe J Sansonetti
Sep 26, 2003·The British Journal of Ophthalmology·B LiA Kijlstra
Jun 29, 2004·Nature Immunology·Tomohiro WatanabeWarren Strober
May 20, 2005·American Journal of Respiratory and Critical Care Medicine·Keertan DhedaAlimuddin Zumla
Sep 2, 2005·Scandinavian Journal of Rheumatology·T AhmadS E Marshall
Aug 3, 2006·The British Journal of Dermatology·A AkmanO Yegin
Jan 11, 2007·Annals of the Rheumatic Diseases·I Koné-PautI Touitou
Mar 6, 2007·Nature Clinical Practice. Rheumatology·Hasan YaziciSebahattin Yurdakul
Mar 14, 2008·Clinical and Experimental Immunology·K NaraN Suzuki
Jun 25, 2008·Proceedings of the National Academy of Sciences of the United States of America·Leo A B JoostenWim B van den Berg
Nov 27, 2010·Journal of Inflammation·Erin I LaffertyMarkus Schnare
Feb 22, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Susanne Billmann-BornPhilip Rosenstiel
Mar 4, 2011·Journal of Neuroimmunology·Kamel HamzaouiHabib Houman
May 5, 2011·The European Respiratory Journal·E KriegovaM Petrek
Jun 28, 2011·Rheumatology·Omar DurraniGraham R Wallace
Sep 15, 2011·Arthritis Research & Therapy·Qingping YaoBo Shen

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Citations

Jan 22, 2014·Rheumatology·Jian QiPeizeng Yang
Aug 14, 2013·Innate Immunity·Noha SeoudiFarida Fortune
Apr 6, 2013·Multidisciplinary Respiratory Medicine·Kamel HamzaouiAgnès Hamzaoui
Nov 22, 2014·Current Opinion in Rheumatology·Emire Seyahi, Hasan Yazici
May 26, 2020·Inflammatory Bowel Diseases·Paul T KrönerFrancis A Farraye
Apr 6, 2017·Mediators of Inflammation·Bunsoon ChoiSeonghyang Sohn

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Methods Mentioned

BETA
X-ray
flow cytometry
lavage
PCR
bronchoalveolar

Software Mentioned

Expo32

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