Nodal cryptococcal immune reconstitution inflammatory syndrome masquerading as tuberculosis in an HIV-infected patient

International Journal of STD & AIDS
A TweddleR F Miller

Abstract

An African HIV-infected patient presented with widespread necrotic lymphadenopathy five months after starting combination antiretroviral therapy (cART) and was thought to have disseminated tuberculosis in the context of an immune reconstitution inflammatory syndrome (IRIS) on the basis of typical imaging appearances and suggestive appearances from a fine needle aspirate of a nodal mass. The patient deteriorated despite empirical antituberculosis therapy and the correct diagnosis of nodal cryptococcal infection was subsequently established by histological examination of a core biopsy from a lymph node. IRIS should be borne in mind when considering the differential diagnosis in a patient who has recently started cART.

References

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Dec 10, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Elizabeth R Jenny-Avital, Maria Abadi
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Mar 24, 2009·International Journal of STD & AIDS·J SeddonR A Ferrand

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Citations

Dec 18, 2012·Current Opinion in Infectious Diseases·Nicky LongleyJoseph N Jarvis

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Methods Mentioned

BETA
biopsy

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