Nodal gamma/delta T cell lymphoma in complete remission following allogeneic bone marrow transplantation from an HLA-matched unrelated donor

Acta Haematologica
Y AoyamaN Tatsumi

Abstract

Gamma/delta T cell lymphoma is very rare, and usually occurs as an extranodal tumor. We describe the case of a 16-year-old Japanese man with an unusual nodal gamma/delta T cell lymphoma with generalized lymphadenopathy and bone marrow involvement. No tumor involvement was observed in the liver, spleen, or nasal cavity. Examination for surface antigens on lymphoma cells revealed a unique phenotype, positive for CD3 and T cell receptor (TCR) gamma/delta, but negative for CD2. Genotypic analysis revealed the tumor to be of monoclonal origin and characterized by TCR gamma-chain gene rearrangement, but there was no rearrangement of the TCR beta-chain gene. Our patient's tumor responded to combination chemotherapy and subsequent allogeneic bone marrow transplantation from an HLA-matched unrelated donor. He has remained well and free of disease for 35 months.

Citations

Aug 19, 2006·Current Treatment Options in Oncology·Sonali M Smith
Apr 28, 2006·Clinical Lymphoma & Myeloma·Peter ReimerMartin Wilhelm
Dec 20, 2011·Histopathology·Socorro M Rodríguez-PinillaMiguel Ángel Piris
Jan 26, 2013·The American Journal of Surgical Pathology·Socorro Maria Rodríguez-PinillaMiguel Ángel Piris

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