Nodal stage of surgically resected non-small cell lung cancer and its effect on recurrence patterns and overall survival

International Journal of Radiation Oncology, Biology, Physics
J VarlottoChristopher R Kelsey

Abstract

Current National Comprehensive Cancer Network guidelines recommend postoperative radiation therapy (PORT) for patients with resected non-small cell lung cancer (NSCLC) with N2 involvement. We investigated the relationship between nodal stage and local-regional recurrence (LR), distant recurrence (DR) and overall survival (OS) for patients having an R0 resection. A multi-institutional database of consecutive patients undergoing R0 resection for stage I-IIIA NSCLC from 1995 to 2008 was used. Patients receiving any radiation therapy before relapse were excluded. A total of 1241, 202, and 125 patients were identified with N0, N1, and N2 involvement, respectively; 161 patients received chemotherapy. Cumulative incidence rates were calculated for LR and DR as first sites of failure, and Kaplan-Meier estimates were made for OS. Competing risk analysis and proportional hazards models were used to examine LR, DR, and OS. Independent variables included age, sex, surgical procedure, extent of lymph node sampling, histology, lymphatic or vascular invasion, tumor size, tumor grade, chemotherapy, nodal stage, and visceral pleural invasion. The median follow-up time was 28.7 months. Patients with N1 or N2 nodal stage had rates of LR similar t...Continue Reading

References

Jan 23, 2004·The New England Journal of Medicine·Rodrigo ArriagadaUNKNOWN International Adjuvant Lung Cancer Trial Collaborative Group
Jun 24, 2005·The New England Journal of Medicine·Timothy WintonUNKNOWN National Cancer Institute of the United States Intergroup JBR.10 Trial Investigators
Jun 14, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Brian E LallyLynn D Wilson
Jan 27, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Haesook T Kim
Sep 1, 2007·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Patti A GroomeUNKNOWN Participating Institutions
Mar 3, 2009·International Journal of Radiation Oncology, Biology, Physics·Senem DemirciLawrence B Marks
Nov 26, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Rodrigo ArriagadaThierry Le Chevalier
Aug 25, 2010·International Journal of Radiation Oncology, Biology, Physics·John M VarlottoMalcolm M DeCamp
Jul 1, 2011·The New England Journal of Medicine·UNKNOWN National Lung Screening Trial Research TeamJoRean D Sicks
Aug 26, 2011·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·J VarlottoM M Decamp
Oct 13, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Valerie W RuschRichard J Cote
Feb 15, 2012·Cancer·Juan P WisniveskyEmilia Bagiella
May 29, 2012·International Journal of Radiation Oncology, Biology, Physics·Laura Medford-DavisJohn Varlotto
Jul 11, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Robert A RamirezRaymond U Osarogiagbon
Mar 15, 2013·The New England Journal of Medicine·Sarah C DarbyPer Hall
Jul 17, 2013·The Journal of Thoracic and Cardiovascular Surgery·Chris R KelseyJohn M Varlotto
Oct 9, 2013·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Charlotte BillietDirk De Ruysscher

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Citations

Mar 22, 2016·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·G Dupic, A Bellière-Calandry
Jul 5, 2016·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Charlotte BillietJeroen Mebis
Oct 30, 2016·Journal of Surgical Oncology·Megan WinnerTimothy M Pawlik
Jun 7, 2019·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·M MajemM Provencio
Jul 21, 2020·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·J M VarlottoK Uy

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