Nodal-staging surgery for locally advanced cervical cancer in the era of PET

The Lancet Oncology
Sebastien GouyEric Leblanc

Abstract

Chemoradiation therapy is deemed the standard treatment by many North American and European teams for treatment of locally advanced cervical cancer. The prevalence of para-aortic nodal metastasis in these tumours is 10-25%. PET (with or without CT) is the most accurate imaging modality to assess extrapelvic disease in such tumours. The true-positive rate of PET is high, suggesting that surgical staging is not necessary if uptake takes place in the para-aortic region. Nevertheless, false-negative results (in the para-aortic region) have been recorded in 12% of patients, rising to 22% in those with uptake during PET of the pelvic nodes. In such situations, laparoscopic surgical para-aortic staging still has an important role for detection of patients with occult para-aortic spread misdiagnosed on PET or PET-CT, allowing optimisation of treatment (extension of radiation therapy fields to include the para-aortic area). Complications of the laparoscopic procedure were noted in 0-7% of patients. Survival of individuals (missed by PET) with para-aortic nodal metastasis of 5 mm or less (and managed by extended field chemoradiation therapy) seems to be similar to survival of those without para-aortic spread, suggesting a positive therap...Continue Reading

References

Jun 1, 1977·American Journal of Obstetrics and Gynecology·J H NelsonR Fruchter
Jul 15, 1990·Cancer·E PodczaskiR Mortel
Feb 15, 1995·International Journal of Radiation Oncology, Biology, Physics·B A FineD Driscoll
Aug 30, 1994·International Journal of Radiation Oncology, Biology, Physics·W J MackillopY Zhou
Mar 10, 1998·Obstetrics and Gynecology·G MichelP Duvillard
Nov 13, 2001·International Journal of Radiation Oncology, Biology, Physics·P W GrigsbyP Eifel
Feb 18, 2003·Physics in Medicine and Biology·R M WyattR G Dale
Feb 24, 2009·International Journal of Radiation Oncology, Biology, Physics·Young Seok KimEun Kyung Choi

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Citations

Oct 12, 2012·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Liangbin XiaKe Wu
Aug 27, 2013·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·I Barillot, A Ruffier Loubière
Aug 27, 2013·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·K Gnep, R Mazeron
Jul 26, 2013·AJR. American Journal of Roentgenology·Sahar MirpourRathan M Subramaniam
Feb 21, 2014·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·LaToya J PerryKathleen Moore
Jan 25, 2014·Clinical Nuclear Medicine·Beatriz DomenechFrancesca Pons
Aug 27, 2013·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Ji-An LiangYin-Yi Chang
May 28, 2014·Best Practice & Research. Clinical Obstetrics & Gynaecology·Antonia Carla TestaRiccardo Manfredi
Sep 10, 2014·Clinical Oncology : a Journal of the Royal College of Radiologists·M L YapM Milosevic
Jul 28, 2013·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·S MarnitzM Mangler
Apr 18, 2013·Acta Obstetricia Et Gynecologica Scandinavica·Maxime FastrezMichel Degueldre
Mar 31, 2015·Best Practice & Research. Clinical Obstetrics & Gynaecology·K Y Tse, Hextan Y S Ngan
Apr 23, 2016·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Jin Hee KimSang-Yoon Park
May 21, 2015·PloS One·Masaru WakatsukiUNKNOWN Working Group of the Gynecological Tumor
Aug 6, 2016·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Renaud MazeronChristine Haie-Meder
Aug 16, 2016·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·I BarillotL Thomas
Aug 30, 2016·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Julie LeseurRenaud De Crevoisier
Aug 31, 2013·Oncology·Pierluigi Benedetti PaniciLudovico Muzii
Jan 28, 2017·BJOG : an International Journal of Obstetrics and Gynaecology·C PomelG Ferron
Dec 25, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Philippe MoriceEric Leblanc
Feb 7, 2017·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Clothilde PetitnicolasEric Leblanc
Oct 1, 2014·Cancers·Andrea GallaminiAnna Borra
May 16, 2014·World Journal of Clinical Oncology·Lucas MinigJesús Garcia-Donas
Jun 2, 2018·Asia-Pacific Journal of Clinical Oncology·Rongxu DuMing Wu
Jun 30, 2018·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Lukas DostalekDavid Cibula
May 14, 2016·Journal of Gynecologic Oncology·Haoran LiXi Cheng
Jul 22, 2014·Journal of Gynecologic Oncology·Dong Hoon SuhKyung-Hun Lee
Jan 30, 2015·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Delphine HudryUNKNOWN SERGS Group
May 4, 2013·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Philippe TummersHelena van Doorn
Dec 17, 2014·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Oona FrankéEric Lambaudie
Aug 14, 2015·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Fabrice NarducciEric Leblanc
Jul 1, 2014·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Roos Marthe SmitsRuud L M Bekkers
Jul 3, 2019·Archives of Gynecology and Obstetrics·Ali AyhanMehmet Mutlu Meydanli

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