Nodding syndrome in Uganda is a tauopathy

Acta Neuropathologica
Michael S PollanenAmanda Fong

Abstract

Nodding syndrome is an epidemic neurologic disorder of unknown cause that affects children in the subsistence-farming communities of East Africa. We report the neuropathologic findings in five fatal cases (13-18 years of age at death) of nodding syndrome from the Acholi people in northern Uganda. Neuropathologic examination revealed tau-immunoreactive neuronal neurofibrillary tangles, pre-tangles, neuropil threads, and dot-like lesions involving the cerebral cortex, subcortical nuclei and brainstem. There was preferential involvement of the frontal and temporal lobes in a patchy distribution, mostly involving the crests of gyri and the superficial cortical lamina. The mesencephalopontine tegmental nuclei, substantia nigra, and locus coeruleus revealed globose neurofibrillary tangles and threads. We conclude that nodding syndrome is a tauopathy and may represent a newly recognized neurodegenerative disease.

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Citations

Sep 26, 2019·Journal of Neuropathology and Experimental Neurology·An HotterbeekxRobert Colebunders
Jan 25, 2020·Annual Review of Pathology·Tory P JohnsonAvindra Nath
Dec 24, 2019·Neuropathology and Applied Neurobiology·Z Jaunmuktane, S Brandner
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Aug 11, 2020·Movement Disorders Clinical Practice·Eoin MulroyKailash P Bhatia
Dec 7, 2019·Global Mental Health·D Geelhand de MerxemR Colebunders
Jan 8, 2021·PLoS Neglected Tropical Diseases·Robert ColebundersJoseph Nelson Siewe Fodjo
Jan 28, 2021·Pathogens·An HotterbeekxRobert Colebunders
Nov 23, 2019·Revue neurologique·P S SpencerM S Pollanen
May 4, 2020·Revue neurologique·P S SpencerM S Pollanen
Dec 1, 2020·Frontiers in Neurology·Jacky Ganguly, Mandar Jog
Apr 4, 2021·Pathogens·Melissa Krizia VieriRobert Colebunders
May 18, 2021·Frontiers in Cellular and Infection Microbiology·An HotterbeekxSamir Kumar-Singh
Jul 6, 2021·Journal of Neural Transmission·Krisztina DanicsGabor G Kovacs

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