PMID: 7012767Jan 1, 1981Paper

Node-based T cell lymphoma. The clinical, immunological and morphological spectrum

Pathology
A S LeongI J Forbes

Abstract

Four cases of node-based T cell lymphoma are presented. The tumours had 2 distinct morphologic patterns. Two cases showed a polymorphous proliferation of pleomorphic lymphoid cells, small lymphocytes, epithelioid cells and arborizing small vessels while the others displayed a monomorphous infiltrate of large atypical lymphoid cells characterized by granular nuclei with numerous tortuous folds to produce a 'squiggly' appearance. One case showed a progression from one histological pattern to the other. Confirmation of the T cell nature of these lymphomas was based on the demonstration of E-rosette formation by morphologically atypical lymphoid cells which also stained positive for acid alpha-naphthyl acetate esterase activity. The patients had an average age of 52 yr and presented with a variable distribution of lymphadenopathy and a predominance of extranodal involvement. Two cases disclosed hypergammaglobulinaemia, one of whom had a paraproteinaemia of IgM-k type. All patients responded poorly to standard combination chemotherapy, 2 expiring 48 and 53 mth after onset of symptoms.

References

Jan 29, 1976·The New England Journal of Medicine·I TsukimotoB C Lampkin
Dec 1, 1976·The Journal of Clinical Investigation·S BroderT A Waldmann
Jul 1, 1978·The British Journal of Dermatology·A S LeongI J Forbes
Jan 1, 1974·International Archives of Allergy and Applied Immunology·D G HaegertR R Coombs
Jul 1, 1974·Journal of Immunological Methods·M E Kaplan, C Clark
Oct 1, 1974·Cancer·R J Lukes, R D Collins

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Citations

Jan 1, 1984·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·S C van der PutteJ A van Unnik
Jan 1, 1981·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·T EimotoM Kikuchi
Jan 1, 1986·Ultrastructural Pathology·N Pinel-BriquelP Stoebner
Jan 1, 1991·The Korean Journal of Internal Medicine·Y H KimI S Kim

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