Node Detection Using High-Dimensional Fuzzy Parcellation Applied to the Insular Cortex

Neural Plasticity
Ugo VercelliFranco Cauda

Abstract

Several functional connectivity approaches require the definition of a set of regions of interest (ROIs) that act as network nodes. Different methods have been developed to define these nodes and to derive their functional and effective connections, most of which are rather complex. Here we aim to propose a relatively simple "one-step" border detection and ROI estimation procedure employing the fuzzy c-mean clustering algorithm. To test this procedure and to explore insular connectivity beyond the two/three-region model currently proposed in the literature, we parcellated the insular cortex of 20 healthy right-handed volunteers scanned in a resting state. By employing a high-dimensional functional connectivity-based clustering process, we confirmed the two patterns of connectivity previously described. This method revealed a complex pattern of functional connectivity where the two previously detected insular clusters are subdivided into several other networks, some of which are not commonly associated with the insular cortex, such as the default mode network and parts of the dorsal attentional network. Furthermore, the detection of nodes was reliable, as demonstrated by the confirmative analysis performed on a replication group...Continue Reading

References

Nov 9, 2005·Trends in Cognitive Sciences·A D Bud Craig
Mar 3, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·William W SeeleyMichael D Greicius
Jun 20, 2007·Proceedings of the National Academy of Sciences of the United States of America·Nico U F DosenbachSteven E Petersen
May 10, 2008·Human Brain Mapping·Peter A Bandettini, Ed Bullmore
May 10, 2008·Neuron·Maurizio CorbettaGordon L Shulman
Aug 30, 2008·Proceedings of the National Academy of Sciences of the United States of America·Devarajan SridharanVinod Menon
Sep 19, 2008·Journal of Neurophysiology·Justin L VincentRandy L Buckner
Dec 17, 2008·Human Brain Mapping·Keri S TaylorKaren D Davis
Dec 20, 2008·Nature Reviews. Neuroscience·A D Bud Craig
Feb 5, 2009·Nature Reviews. Neuroscience·Ed Bullmore, Olaf Sporns
Apr 3, 2009·Journal of Neurophysiology·Michael D FoxMarcus E Raichle
Apr 10, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Gordon L ShulmanMaurizio Corbetta
May 12, 2009·Neuroscience Letters·Isabella MutschlerTonio Ball
Jun 10, 2009·Human Brain Mapping·Vesa KiviniemiOsmo Tervonen
Oct 14, 2009·Cerebral Cortex·Florian KurthKatrin Amunts
Jun 1, 2010·Brain Structure & Function·Dana M Small
Jun 1, 2010·Brain Structure & Function·Steven M NelsonSteven E Petersen
Jul 14, 2010·Neuron·Steven M NelsonSteven E Petersen
Sep 8, 2010·NeuroImage·Stephen M SmithMark W Woolrich
Sep 24, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Neil A HarrisonHugo D Critchley
Oct 12, 2010·PloS One·Franco CaudaAndrea E Cavanna
Nov 26, 2010·Cerebral Cortex·Ben DeenKevin A Pelphrey
Nov 30, 2010·NeuroImage·Franco CaudaAlessandro Vercelli
Mar 25, 2011·Journal of Neurophysiology·Gaëlle DoucetMarc Joliot
May 4, 2011·Annals of the New York Academy of Sciences·A D Bud Craig
Jun 10, 2011·Journal of Neurophysiology·B T Thomas YeoRandy L Buckner
Oct 18, 2011·Brain Topography·András JakabErvin L Berényi
Nov 22, 2011·Neuron·Jonathan D PowerSteven E Petersen
Jan 6, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Robert LeechDavid J Sharp
Jan 31, 2012·Brain Structure & Function·Franco CaudaAlessandro Vercelli
Feb 11, 2012·Proceedings of the National Academy of Sciences of the United States of America·Stephen M SmithKamil Ugurbil

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Methods Mentioned

BETA
PCA

Software Mentioned

BrainVoyager QX

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.