PMID: 6534973Dec 1, 1984Paper

Nodes of Ranvier and Schmidt-Lanterman incisures: an in vivo lanthanum tracer study

Journal of Neurocytology
M L MacKenzieG Allt

Abstract

The permeability of the tight junctional system of myelin, at the juxtanodal myelin terminal loops and Schmidt-Lanterman incisures, was investigated using the ionic tracer lanthanum (a) in vivo followed by fixation, (b) concurrently with fixation, (c) following fixation. Employing the same methods the juxtanodal membrane complex formed between myelin loops and axolemma was also tested. The results of this study demonstrate that the periaxonal space (between axon and Schwann cell) is apparently accessible to lanthanum via the myelin loop-axolemmal junction, irrespective of the mode of exposure of myelinated fibres to the tracer. Similarly, the tight junctions between adjacent myelin terminal loops apparently do not prevent lanthanum penetration either in living or in fixed nerves. By contrast the tracer obtained access to the extracellular space within incisures only in vivo. The results are interpreted in terms of the permeability of nodes and incisures in vivo to physiologically important ions and related to current concepts of the electrophysiology of the myelinated nerve fibre.

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Citations

Jan 1, 1987·Acta Neuropathologica·C E BlanchardG Allt
Jun 1, 1993·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Y N HuiK Heimann
Aug 1, 1993·Journal of Neurocytology·K FriedM Devor
Dec 1, 1985·Journal of Neurocytology·C E BlanchardG Allt
Sep 1, 1994·Journal of Neurocytology·V Shinder, M Devor
Feb 1, 2008·Journal of Molecular Neuroscience : MN·Jennifer L Orthmann-MurphySteven S Scherer
May 1, 1985·Journal of Ultrastructure Research·G AlltK Sikri
Jan 1, 1992·Electron Microscopy Reviews·K Meller
Jun 1, 1997·Brain Research. Brain Research Reviews·G Allt, J G Lawrenson
Dec 10, 1999·Annals of the New York Academy of Sciences·S S Scherer
Nov 26, 2010·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Shin KikuchiTakashi Kojima
Sep 8, 2010·Cellular and Molecular Life Sciences : CMLS·Floriano RodriguesChristian Klämbt
Oct 15, 2013·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Jack RosenbluthSeema Shroff
Apr 10, 2002·Journal of the Peripheral Nervous System : JPNS·Steven S Scherer, Edgardo J Arroyo
May 28, 2011·Glia·Seema ShroffJack Rosenbluth
Oct 1, 1999·Annals of the New York Academy of Sciences·Steven S Scherer

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