NOD.H-2h4 mice: an important and underutilized animal model of autoimmune thyroiditis and Sjogren's syndrome

Advances in Immunology
H Braley-Mullen, S Yu

Abstract

NOD.H-2h4 mice express the K haplotype on the NOD genetic background. They spontaneously develop thyroiditis and Sjogren's syndrome, but they do not develop diabetes. Although autoimmune thyroid diseases and Sjogren's syndrome are highly prevalent autoimmune diseases in humans, there has been relatively little emphasis on the use of animal models of these diseases for understanding basic mechanisms involved in development and therapy of chronic organ-specific autoimmune diseases. The goal of this review is to highlight some of the advantages of NOD.H-2h4 mice for studying basic mechanisms involved in development of autoimmunity. NOD.H-2h4 mice are one of relatively few animal models that develop organ-specific autoimmune diseases spontaneously, i.e., without a requirement for immunization with antigen and adjuvant, and in both sexes in a relatively short period of time. Thyroiditis and Sjogren's syndrome in NOD.H-2h4 mice are chronic autoimmune diseases that develop relatively early in life and persist for the life of the animal. Because the animals do not become clinically ill, the NOD.H-2h4 mouse provides an excellent model to test therapeutic protocols over a long period of time. The availability of several mutant mice on th...Continue Reading

Citations

Feb 26, 2016·Annual Review of Immunology·Emil R UnanueJacques Neefjes
Jun 15, 2016·Thyroid : Official Journal of the American Thyroid Association·Rajni SharmaPatrizio Caturegli
Aug 6, 2016·Auto- Immunity Highlights·Giulia Di DalmaziPatrizio Caturegli
Jan 25, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Giulia Di DalmaziPatrizio Caturegli
Jun 12, 2019·Thyroid : Official Journal of the American Thyroid Association·Sandra M McLachlanBasil Rapoport
Nov 1, 2016·Science Translational Medicine·Tamer I MahmoudRachel Ettinger
Jan 31, 2020·The Journal of Clinical Endocrinology and Metabolism·Debora RicciFrancesco Latrofa
Aug 16, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Timothy Daniel KayesHelen Braley-Mullen
Apr 6, 2018·Thyroid : Official Journal of the American Thyroid Association·Sandra M McLachlan, Basil Rapoport
Dec 4, 2020·International Journal of Molecular Sciences·Sharmila Masli, Darlene A Dartt
Sep 25, 2020·Minerva endocrinologica·Rosaria M RuggeriSebastiano Gangemi
May 11, 2021·Frontiers in Immunology·Manuel Sáez MoyaPablo Engel

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