PMID: 4076734Dec 1, 1985Paper

Nodular hyperplasia of Brunner's glands

Gastrointestinal Endoscopy
G FranzinA Fratton


A clinical, endoscopic, and histological study of 206 cases of nodular hyperplasia of Brunner's glands was carried out. Firm nodules with a reddened surface due to hyperplastic Brunner's glands were limited mainly to the first part of the duodenum and affected almost exclusively male patients. Gastric acid secretion after pentagastrin stimulation was significantly increased compared to normal. In most cases, biopsies of the nodule center revealed spreading of Brunner's glands from within the lamina propria to the surface epithelium, whereas in biopsies performed between nodules, Brunner's glands were limited to the deeper part of the mucosa. Thirty-six nodules completely removed by diathermy were composed almost entirely of Brunner's glands. The frequent association with duodenal ulcer, chronic gastric erosions, and cobblestone pattern of the gastric body mucosa, as well as the significant hypersecretory state, suggest that hyperacidity plays a role in the pathogenesis of nodular hyperplasia of Brunner's glands.


Jan 1, 1991·Gastrointestinal Radiology·D MerineT M Bayless
Dec 16, 2006·Digestive Diseases and Sciences·Reina OhbaSumio Watanabe
Nov 20, 2009·Journal of Gastrointestinal Cancer·Rizwan KibriaSalma Akram
Jan 26, 2016·The Korean Journal of Internal Medicine·In Tae HwangTae Hyeon Kim
Aug 23, 2006·Gastrointestinal Endoscopy·Padmini KrishnamurthyN Gopalswamy
Sep 11, 2012·Veterinary Pathology·T J Steinbach, J D Kane
May 18, 2013·Journal of Veterinary Internal Medicine·A KullmannR C Smedley
Jun 26, 2020·Journal of Medical Primatology·David WalkerLinda R Morrison
Apr 13, 2006·World Journal of Gastroenterology : WJG·Alba RoccoGerardo Nardone
Sep 8, 2017·Case Reports in Gastroenterology·Edward MeltserKathryn C Behling
Jun 13, 2019·Canadian Journal of Gastroenterology & Hepatology·Sabahattin Destek, Vahit Onur Gul
Apr 6, 2021·Open Life Sciences·Bo YangDengyang Fang
Dec 3, 2015·Gastroenterology·Wei-Yao HsiehMing-Chih Hou

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.


Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.