PMID: 6985832Jan 15, 1980Paper

Nodular mixed lymphocytic-histiocytic lymphoma (NM): response and survival. Eastern Cooperative Oncology Group

Cancer
E Z EzdinliP P Carbone

Abstract

Eighty patients with nodular mixed lymphocytic-histiocytic lymphoma (NM) entered on four different Eastern Cooperative Oncology Group chemotherapy studies were analyzed for response and survival. They were compared with 249 patients with nodular lymphocytic poorly differentiated lymphoma (NLPD), who were treated similarly. The response rates in NM were: CR 45%, PR 30%, NC-PD 25%. In NLPD the quality of response had little effect on survival (CR 91%, PR 90%, NC-PD 76%), whereas in NM the two year survivorship of 85% for CR dropped drastically to 33% for the partial responders (P less than 0.01). Ninety percent of the previously untreated NLPD, but only 59% of the comparable group of NM, survived 2 years. In 23 patients with NM in which the pattern was reported as both nodular and diffuse (ND-M), the 2-year survival of 35% was markedly inferior to a 66% 2-year survivorship observed in 57 patients with the pure nodular pattern (P less than 0.05). It appears that NM is a less favorable lymphoma type than NLPD. In NM achievement of a CR affects survival favorably; consequently, the use of aggressive chemotherapy regimens in an attempt to achieve high rates of CR are recommended. In NLPD, on the other hand, since survival curves of p...Continue Reading

Citations

Sep 1, 1981·Blut·K Musshoff, H Brücher
Mar 1, 1996·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J W DenhamG V Hudson
Apr 27, 1999·Australian Dental Journal·V I UgbokoM A Durosinmi
Mar 1, 1991·Journal of Clinical Pathology·J C MacartneyA Timothy
Jul 1, 1983·International Journal of Radiation Oncology, Biology, Physics·M P CorderJ M Lovett
Jan 1, 1982·Medical and Pediatric Oncology·J Z FuksP H Wiernik
Sep 3, 1990·The Medical Journal of Australia·P C Vincent

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