PMID: 43015Jan 1, 1979

Nodular paragranuloma and progressively transformed germinal centers. Ultrastructural and immunohistologic findings

Virchows Archiv. B, Cell Pathology Including Molecular Pathology
S PoppemaK Lennert

Abstract

Ultrastructural and immunohistologic findings in a nodular variant of Hodgkin's disease with lymphocytic predominance, called nodular paragranuloma, are presented and compared with those in so-called progressively transformed germinal centers. These are large follicles with numerous lymphocytes which can be found not only in nonspecific lymphadenitis, but also in lymph nodes from patients with nodular paragranuloma. The immunoperoxidase technique was applied on paraffin sections to detect intracytoplasmic immunoglobulin and lysozyme. The so-called L & H type Sternberg-Reed cells contained IgG and one type of light chain per cell, suggesting that such cells produce immunoglobulin. The ultrastructure of the L & H type Sternberg-Reed cells favored the immunoblastic nature of these cells. It is concluded that nodular paragranuloma differs from other types of Hodgkin's disease by its localization in B-cell areas and the presence of atypical B immunoblasts.

References

Mar 1, 1997·Medical and Pediatric Oncology·R EpelbaumN Haim
Jan 1, 1984·Journal of Cancer Research and Clinical Oncology·M L HansmannK Lennert
Jan 1, 1981·Journal of Cancer Research and Clinical Oncology·M L Hansmann, E Kaiserling
Sep 1, 1979·Journal of Cancer Research and Clinical Oncology·S PoppemaK Lennert
Jan 1, 1986·Virchows Archiv. A, Pathological Anatomy and Histopathology·M L HansmannH J Radzun
Jan 1, 1989·Virchows Archiv. A, Pathological Anatomy and Histopathology·G Li, M L Hansmann
Jan 1, 1990·Virchows Archiv. A, Pathological Anatomy and Histopathology·J TamaruT Takagi
Jan 15, 1995·International Journal of Radiation Oncology, Biology, Physics·E CrennanG Quong
Mar 27, 2003·The American Journal of Surgical Pathology·Lekidelu Taddesse-HeathElaine S Jaffe
Apr 25, 2009·The Cancer Journal·Franziska C EberleElaine S Jaffe
Jan 1, 1991·Histopathology·P W BishopK J Elsam
Jul 1, 1984·Journal of Clinical Pathology·C S Morris, A E Stuart
Sep 1, 1986·Journal of Clinical Pathology·M W Myskow, A S Krajewski
Dec 1, 1993·Leukemia & Lymphoma·J DelabieC De Wolf-Peeters
Sep 1, 1994·Leukemia & Lymphoma·S PetraschM Kosco-Vilbois
Dec 1, 1989·Pathology, Research and Practice·T PetrellaP Fargeot
Jun 16, 2009·Clinical Lymphoma & Myeloma·Haresh Mani, Elaine S Jaffe
Jul 14, 2005·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Asa Nilsdotter-AugustinssonLena Ohman
Oct 1, 1993·Human Pathology·S M HsuA J Hough
Jan 15, 1988·International Journal of Cancer. Journal International Du Cancer·T KarttunenH Autio-Harmainen
Sep 1, 1987·The Journal of Pathology·C A AngelI Lauder
Mar 15, 1982·International Journal of Cancer. Journal International Du Cancer·H SteinP Wernet
Nov 1, 1991·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·E M BessellF D Dowling
May 3, 2016·Clinical Lymphoma, Myeloma & Leukemia·Melda Cömert ÖzkanMahmut Töbü
Jan 28, 1988·The New England Journal of Medicine·D P RegulaL M Weiss
Jul 28, 1988·The New England Journal of Medicine

Citations

Sep 1, 1979·Journal of Cancer Research and Clinical Oncology·S PoppemaK Lennert
Sep 1, 1968·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·P K Nakane
Apr 1, 1966·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·R C Graham, M J Karnovsky

Related Concepts

Lymphoid Cells
Immunoglobulins
B-Lymphocytes
Electron Microscopy
Lymphadenitis
Polyglobin
Leftose
Hodgkin Disease
Peroxidase-Antiperoxidase Complex Technique
Hodgkin Lymphoma, Lymphocyte Depletion

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