PMID: 43015Jan 1, 1979

Nodular paragranuloma and progressively transformed germinal centers. Ultrastructural and immunohistologic findings

Virchows Archiv. B, Cell Pathology Including Molecular Pathology
S PoppemaK Lennert


Ultrastructural and immunohistologic findings in a nodular variant of Hodgkin's disease with lymphocytic predominance, called nodular paragranuloma, are presented and compared with those in so-called progressively transformed germinal centers. These are large follicles with numerous lymphocytes which can be found not only in nonspecific lymphadenitis, but also in lymph nodes from patients with nodular paragranuloma. The immunoperoxidase technique was applied on paraffin sections to detect intracytoplasmic immunoglobulin and lysozyme. The so-called L & H type Sternberg-Reed cells contained IgG and one type of light chain per cell, suggesting that such cells produce immunoglobulin. The ultrastructure of the L & H type Sternberg-Reed cells favored the immunoblastic nature of these cells. It is concluded that nodular paragranuloma differs from other types of Hodgkin's disease by its localization in B-cell areas and the presence of atypical B immunoblasts.


Mar 1, 1997·Medical and Pediatric Oncology·R EpelbaumN Haim
Jan 1, 1984·Journal of Cancer Research and Clinical Oncology·M L HansmannK Lennert
Jan 1, 1981·Journal of Cancer Research and Clinical Oncology·M L Hansmann, E Kaiserling
Sep 1, 1979·Journal of Cancer Research and Clinical Oncology·S PoppemaK Lennert
Jan 1, 1986·Virchows Archiv. A, Pathological Anatomy and Histopathology·M L HansmannH J Radzun
Jan 1, 1989·Virchows Archiv. A, Pathological Anatomy and Histopathology·G Li, M L Hansmann
Jan 1, 1990·Virchows Archiv. A, Pathological Anatomy and Histopathology·J TamaruT Takagi
Jan 15, 1995·International Journal of Radiation Oncology, Biology, Physics·E CrennanG Quong
Mar 27, 2003·The American Journal of Surgical Pathology·Lekidelu Taddesse-HeathElaine S Jaffe
Apr 25, 2009·The Cancer Journal·Franziska C EberleElaine S Jaffe
Jan 1, 1991·Histopathology·P W BishopK J Elsam
Jul 1, 1984·Journal of Clinical Pathology·C S Morris, A E Stuart
Sep 1, 1986·Journal of Clinical Pathology·M W Myskow, A S Krajewski
Dec 1, 1993·Leukemia & Lymphoma·J DelabieC De Wolf-Peeters
Sep 1, 1994·Leukemia & Lymphoma·S PetraschM Kosco-Vilbois
Dec 1, 1989·Pathology, Research and Practice·T PetrellaP Fargeot
Jun 16, 2009·Clinical Lymphoma & Myeloma·Haresh Mani, Elaine S Jaffe
Jul 14, 2005·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Asa Nilsdotter-AugustinssonLena Ohman
Oct 1, 1993·Human Pathology·S M HsuA J Hough
Jan 15, 1988·International Journal of Cancer. Journal International Du Cancer·T KarttunenH Autio-Harmainen
Sep 1, 1987·The Journal of Pathology·C A AngelI Lauder
Mar 15, 1982·International Journal of Cancer. Journal International Du Cancer·H SteinP Wernet
Nov 1, 1991·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·E M BessellF D Dowling
May 3, 2016·Clinical Lymphoma, Myeloma & Leukemia·Melda Cömert ÖzkanMahmut Töbü
Jan 28, 1988·The New England Journal of Medicine·D P RegulaL M Weiss
Jul 28, 1988·The New England Journal of Medicine


Sep 1, 1979·Journal of Cancer Research and Clinical Oncology·S PoppemaK Lennert
Sep 1, 1968·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·P K Nakane
Apr 1, 1966·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·R C Graham, M J Karnovsky

Related Concepts

Lymphoid Cells
Electron Microscopy
Hodgkin Disease
Peroxidase-Antiperoxidase Complex Technique
Hodgkin Lymphoma, Lymphocyte Depletion

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Synapse Loss as Therapeutic Target in MS

As we age, the number of synapses present in the human brain starts to decline, but in neurodegenerative diseases this occurs at an accelerated rate. In MS, it has been shown that there is a reduction in synaptic density, which presents a potential target for treatment. Here is the latest research on synapse loss as a therapeutic target in MS.

Artificial Intelligence in Cardiac Imaging

Artificial intelligence (ai) techniques are increasingly applied to cardiovascular (cv) medicine in cardiac imaging analysis. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

Social Learning

Social learning involves learning new behaviors through observation, imitation and modeling. Follow this feed to stay up to date on the latest research.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Single Cell Chromatin Profiling

Techniques like ATAC-seq and CUT&Tag have the potential to allow single cell profiling of chromatin accessibility, histones, and TFs. This will provide novel insight into cellular heterogeneity and cell states. Discover the latest research on single cell chromatin profiling here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells.