Nodular scleroderma: focally increased tenascin expression differing from that in the surrounding scleroderma skin

The Journal of Dermatology
H MizutaniM Shimizu

Abstract

Nodular scleroderma is a rare variant of the disease, whose pathogenesis is uncertain. Tenascin is a recently cloned extracellular matrix protein which is thought to be a marker for tissue remodelling. To further investigate the pathogenesis of nodular scleroderma, we have followed up a case of this disease and studied tenascin expression in the nodular lesions and surrounding progressive systemic sclerosis skin. Previously, we demonstrated a long-lasting intermediate level of dermal tenascin expression in progressive systemic sclerosis; morphea and hypertrophic scar lesions showed strong but short-lived tenascin expression. In our current patient, high levels of tenascin were found in the nodules, which rapidly resolved. Thus, the time course of the clinical and histopathological findings together with the tenascin expression were more suggestive of hypertrophic scar than progressive systemic sclerosis. These findings imply that nodular scleroderma has a supplementary pathogenesis, such as itching, in addition to the proceeding systemic sclerosis.

References

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Citations

Dec 24, 2015·Case Reports in Dermatological Medicine·Sama KassiraNaveed Sami
Jul 10, 2013·The Journal of Dermatology·Kuniko InoueHironobu Ihn
Aug 16, 2011·Journal of the European Academy of Dermatology and Venereology : JEADV·G P Sidgwick, A Bayat
Dec 21, 2000·The British Journal of Dermatology·T K GilmourS Kossard
Oct 10, 1998·The British Journal of Dermatology·U WollinaD Lange
Jul 23, 2008·The American Journal of Dermatopathology·Cooper C WristonGlen H Crawford
Oct 6, 2005·Dermatology : International Journal for Clinical and Investigative Dermatology·Toshiyuki YamamotoKiyoshi Nishioka
Jul 10, 2013·Archives of Dermatological Research·P MoinzadehT Krieg
Jan 30, 2004·Clinical Rheumatology·Mittermayer SantiagoAriene Paixão
Jul 24, 2003·The American Journal of Dermatopathology·Aviv BarzilaiHenri Trau
Mar 26, 2003·Clinical and Experimental Dermatology·T C LingC E M Griffiths
Feb 14, 2006·The Journal of Dermatology·Lucilla MelaniPaolo Fabbri

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