Nogo-B promotes tumor angiogenesis and provides a potential therapeutic target in hepatocellular carcinoma

Molecular Oncology
Hao CaiLong Yu

Abstract

Tumor angiogenesis is one of the hallmarks of cancer as well as an attractive target for cancer therapy. Characterization of novel pathways that act in parallel with the VEGF/VEGFR axis to promote tumor angiogenesis may provide insights into novel anti-angiogenic therapeutic targets. We found that the expression level of Nogo-B is positively correlated with tumor vessel density in hepatocellular carcinoma (HCC). While Nogo-B depletion inhibited tumor angiogenesis, Nogo-B overexpression promoted tumor angiogenesis in a tumor xenograft subcutaneous model of the human HCC cell line. Mechanically, Nogo-B regulates tumor angiogenesis based on its association with integrin αv β3 and activation of focal adhesion kinase. Moreover, Nogo-B antibody successfully abolished the function of Nogo-B in tumor angiogenesis in vitro and in vivo. Collectively, our results strongly suggest that Nogo-B is an important tumor angiogenic factor and blocking Nogo-B selectively inhibits tumor angiogenesis.

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Citations

Feb 19, 2019·Journal of Cellular Biochemistry·Baojin XuJie Lin
Apr 21, 2019·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Qing LiXuehao Wang
Mar 13, 2020·International Journal of Cancer. Journal International Du Cancer·Sarun JuengpanichXiujun Cai
Nov 7, 2019·Cellular and Molecular Life Sciences : CMLS·Roberta LuganoAnna Dimberg

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Methods Mentioned

BETA
transfection
xenograft
immunoprecipitation
ELISA

Software Mentioned

imagej

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