Nogo in the injured spinal cord

Journal of Neurotrauma
Rüdiger Schweigreiter, Christine E Bandtlow

Abstract

Myelin of the adult mammalian central nervous system (CNS) has been attributed to suppress structural plasticity and to impede regenerating nerve fibers. Nogo-A is possibly the best characterized of a variety of neurite growth inhibitors present in CNS myelin. Neutralizing its activity results in improved axon regrowth and functional recovery in experimental CNS lesion models of adult rodents and primates. While Nogo-A has become a major target for therapeutic intervention to promote axon regeneration in the CNS, it is realized that such an approach will likely have to be combined with other therapeutic strategies to maximize functional recovery after spinal cord injury (SCI).

References

Dec 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·H S KeirsteadJ D Steeves
Apr 1, 1985·Experimental Neurology·J R WrathallF Harvey
Mar 20, 1980·Nature·P M RichardsonA J Aguayo
Feb 1, 1995·Journal of Neurotrauma·D M BassoJ C Bresnahan
Feb 7, 1998·Science·A Hall
Jul 21, 1998·The Journal of Biological Chemistry·A A SpillmannM E Schwab
Mar 5, 1999·Spinal Cord·B A Kakulas
Jun 26, 1999·The European Journal of Neuroscience·M OudegaM B Bunge
Feb 10, 2000·Nature·R PrinjhaF S Walsh
Jun 29, 2000·Annual Review of Biochemistry·K KaibuchiM Amano
Apr 3, 2001·Nature Reviews. Neuroscience·O Raineteau, M E Schwab
May 16, 2002·The Journal of Cell Biology·Toshihide YamashitaMasaya Tohyama
May 31, 2002·Nature·Tadzia GrandPréStephen M Strittmatter
Jun 28, 2002·Neuron·Jin QiuMarie T Filbin
Jun 29, 2002·Science·Betty P LiuStephen M Strittmatter
Jul 27, 2002·Annual Review of Cell and Developmental Biology·Liqun Luo
Oct 2, 2002·Journal of Neurochemistry·Vicky KottisPeter E Braun
Oct 9, 2002·Current Opinion in Neurobiology·Jean-Antoine Girault, Elior Peles
Nov 15, 2002·The European Journal of Neuroscience·Olivier RaineteauMartin E Schwab
Dec 10, 2002·Science·Barry J Dickson
Apr 2, 2003·Trends in Cell Biology·Thomas Oertle, Martin E Schwab
Apr 15, 2003·Molecular and Cellular Neurosciences·Jaimie F BorisoffWolfram Tetzlaff
Apr 30, 2003·Neuron·Ji Eun KimStephen M Strittmatter
Apr 30, 2003·Neuron·Binhai ZhengMarc Tessier-Lavigne

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Citations

Feb 22, 2012·Cell and Tissue Research·M A KoppJ M Schwab
May 1, 2008·Neuron Glia Biology·Rüdiger Schweigreiter
Jan 20, 2011·Surgical Neurology International·Zain A SobaniS Ather Enam
Jan 29, 2008·British Journal of Neurosurgery·S Knafo, D Choi
Aug 6, 2011·Progress in Neurobiology·Giulietta RiboldiStefania Corti
Dec 5, 2015·Frontiers in Cellular Neuroscience·Christoph EckharterRüdiger Schweigreiter
Apr 18, 2007·The FEBS Journal·Hilke ZanderArne Skerra
Dec 21, 2007·The European Journal of Neuroscience·Gabriela ChytrovaFernando Gomez-Pinilla
Apr 18, 2015·Neural Regeneration Research·Jian-Wei WangYa-Feng Zhang
Aug 6, 2013·The Biochemical Journal·Florian KernRüdiger Schweigreiter
Aug 21, 2013·Molecular and Cellular Biochemistry·Felicia Yu Hsuan Teng, Bor Luen Tang
Aug 30, 2020·Neural Regeneration Research·Robert B Shultz, Yinghui Zhong
Jun 16, 2017·Neural Regeneration Research·Robert B Shultz, Yinghui Zhong

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