Noise in solid-state nanopores

Proceedings of the National Academy of Sciences of the United States of America
R M M SmeetsC Dekker

Abstract

We study ionic current fluctuations in solid-state nanopores over a wide frequency range and present a complete description of the noise characteristics. At low frequencies (f approximately < 100 Hz) we observe 1/f-type of noise. We analyze this low-frequency noise at different salt concentrations and find that the noise power remarkably scales linearly with the inverse number of charge carriers, in agreement with Hooge's relation. We find a Hooge parameter alpha = (1.1 +/- 0.1) x 10(-4). In the high-frequency regime (f approximately > 1 kHz), we can model the increase in current power spectral density with frequency through a calculation of the Johnson noise. Finally, we use these results to compute the signal-to-noise ratio for DNA translocation for different salt concentrations and nanopore diameters, yielding the parameters for optimal detection efficiency.

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Citations

Nov 20, 2012·Chemical Reviews·Joseph E ReinerJohn J Kasianowicz
May 5, 2012·Nano Letters·Gautam V Soni, Cees Dekker
Mar 6, 2013·Nano Letters·Yi LiPol Van Dorpe
Aug 16, 2011·ACS Nano·Sergei N SmirnovNickolay V Lavrik
Dec 14, 2012·ACS Nano·Agnieszka RutkowskaTim Albrecht
Sep 16, 2009·ACS Nano·Vincent Tabard-CossaAndre Marziali
Mar 20, 2012·Nature Methods·Jacob K RosensteinKenneth L Shepard
Nov 30, 2010·Nature Nanotechnology·Adam R HallCees Dekker
Jun 21, 2011·Nature Nanotechnology·Stefan W KowalczykCees Dekker
May 31, 2012·The Analyst·Edward M NelsonGregory Timp
Dec 3, 2008·The Journal of Chemical Physics·Vladimir Yu ZitsermanSergey M Bezrukov
Mar 25, 2014·PloS One·Harold KwokVincent Tabard-Cossa
Jun 20, 2012·Applied Physics Letters·Aaron T Kuan, Jene A Golovchenko
Mar 26, 2014·Nanoscale Research Letters·Lingzhi WuZuhong Lu
Mar 1, 2013·ACS Nano·David J NiedzwieckiLiviu Movileanu
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