Noise-induced neurodegeneration in the central auditory pathway : An overview of experimental studies in a mouse model
Abstract
A noise trauma induces central nervous system pathologies, which generate deficits in hearing and perception of sound. Are degenerative mechanisms in the central auditory system a direct impact of overstimulation or an effect of acoustic deprivation? Detection of cell death in a mouse model of noise-induced hearing loss at different times after single or repeated noise exposure. A single noise exposure (3 h, 115 dB SPL, 5-20 kHz) induces acute (≤1 day) and long-term (observation period 14 days) degeneration, particularly in subcortical structures. Repeated noise trauma is followed by pathologies in the auditory thalamus and cortex. Noise has a direct impact on basal structures of the central auditory system; a protection of cortical areas is possibly due to inhibitory neuronal projections. Degenerative mechanisms in higher structures of the pre-damaged system point to an increased impairment of complex processing of acoustic information.
References
Short-term synaptic depression and recovery at the mature mammalian endbulb of Held synapse in mice.
Citations
Related Concepts
Related Feeds
Auditory Perception
Auditory perception is the ability to receive and interpret information attained by the ears. Here is the latest research on factors and underlying mechanisms that influence auditory perception.