Noise-induced neurodegeneration in the central auditory pathway : An overview of experimental studies in a mouse model

HNO
Moritz GröschelDietmar Basta

Abstract

A noise trauma induces central nervous system pathologies, which generate deficits in hearing and perception of sound. Are degenerative mechanisms in the central auditory system a direct impact of overstimulation or an effect of acoustic deprivation? Detection of cell death in a mouse model of noise-induced hearing loss at different times after single or repeated noise exposure. A single noise exposure (3 h, 115 dB SPL, 5-20 kHz) induces acute (≤1 day) and long-term (observation period 14 days) degeneration, particularly in subcortical structures. Repeated noise trauma is followed by pathologies in the auditory thalamus and cortex. Noise has a direct impact on basal structures of the central auditory system; a protection of cortical areas is possibly due to inhibitory neuronal projections. Degenerative mechanisms in higher structures of the pre-damaged system point to an increased impairment of complex processing of acoustic information.

References

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Oct 27, 2015·Anatomical Science International·Tetsufumi ItoDouglas L Oliver
May 29, 2016·Hearing Research·Jos J Eggermont

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