Noise magnetic fields abolish the gap junction intercellular communication suppression induced by 50 hz magnetic fields

Bioelectromagnetics
Qun-li ZengZheng-ping Xu

Abstract

Previously, we have reported that exposure to 50 Hz coherent sinusoidal magnetic fields (MF) for 24 h inhibits gap junction intercellular communication (GJIC) in mammalian cells at an intensity of 0.4 mT and enhances the inhibition effect of 12-O-tetradecanoylphorbol-13-acetate (TPA) at 0.2 mT. In the present study, we further explored the effects of incoherent noise MF on MF-induced GJIC inhibition. GJIC was determined by fluorescence recovery after photobleaching (FRAP) with a laser-scanning confocal microscope. The rate of fluorescence recovery (R) at 10 min after photobleaching was adopted as the functional index of GJIC. The R-value of NIH3T3 cells exposed to 50 Hz sinusoidal MF at 0.4 mT for 24 h was 30.85 +/- 14.70%, while the cells in sham exposure group had an R-value of 46.36 +/- 20.68%, demonstrating that the GJIC of NIH3T3 cells was significantly inhibited by MF exposure (P < .05). However, there were no significant differences in the R-values of the sham exposure, MF-plus-noise MF exposure (R: 49.58 +/- 19.38%), and noise MF exposure groups (R: 46.74 +/- 21.14%) (P > .05), indicating that the superposition of a noise MF alleviated the suppression of GJIC induced by the 50 Hz MF. In addition, although MF at an inten...Continue Reading

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Citations

Aug 17, 2010·Electromagnetic Biology and Medicine·Kjell Hansson Mild, Mats-Olof Mattsson
May 9, 2008·International Journal of Radiation Biology·X Q KeH Chiang
Apr 8, 2015·Bioelectromagnetics·Yann PercherancierBernard Veyret
Jul 6, 2010·Journal of Cardiovascular Pharmacology and Therapeutics·Jing ShenShen-Jiang Hu

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