PMID: 1214277Dec 4, 1975Paper

Noise measurements in squid axon membrane

The Journal of Membrane Biology
H M FishmanL E Moore

Abstract

A small area (10(-4) to 10(-5) cm2 patch) of the external surface of a squid (Loligo pealei) axon was "isolated" electrically by means of a pair of concentric glass pipettes and sucrose solution to achieve a low extraneous noise measurement of spontaneous fluctuations in membrane potential and current. The measured "small-signal" impedance function of the isolated patch in seawater was constant at low frequencies and declined monotonically at frequencies beyond 100Hz. It is shown that the power-density spectrum (PDS) of voltage noise, which generally reflects the current-noise spectrum filtered by the membrane impedance function, is equivalent to the power spectrum of current-noise up to frequencies where the impedance decline is significant (Fishman, 1973a, Proc. Nat. Acad. Sci. USA 70:876). This result is in contrast to an impedance resonance measured under uniform constant-current (internal axial wire) conditions, for which the voltage-noise PDS reflects the impedance resonance. The overdamped resonance in the patch technique is a consequence of the relatively low resistance (1 Momega) pathways through the sucrose solution in the interstitial Schwann cell space which surround and shunt the high resistance (10-100 Momega) mem...Continue Reading

References

Dec 4, 1975·The Journal of Membrane Biology·H M Fishman
Dec 4, 1975·The Journal of Membrane Biology·H M FishmanD M Poussart
Feb 18, 1974·Pflügers Archiv : European journal of physiology·E WankeF Conti
Mar 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·H M Fishman
Sep 1, 1973·IEEE Transactions on Bio-medical Engineering·H M Fishman
Dec 1, 1973·Biophysical Journal·H M Fishman, D L Dorset
Aug 1, 1972·The Journal of Physiology·B Katz, R Miledi
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Mar 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·G Feher, M Weissman

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Citations

Sep 1, 1980·Pflügers Archiv : European journal of physiology·W Finger, H Stettmeier
Dec 4, 1975·The Journal of Membrane Biology·H M Fishman
Dec 4, 1975·The Journal of Membrane Biology·H M FishmanD M Poussart
Oct 5, 1979·The Journal of Membrane Biology·H M FishmanL E Moore
Jun 30, 1976·The Journal of Membrane Biology·L E Moore, E Neher
May 21, 1979·The Journal of Membrane Biology·L E MooreD J Poussart
Apr 22, 1977·The Journal of Membrane Biology·H M FishmanE Siebenga
Dec 15, 1977·The Journal of Membrane Biology·H A Kolb, P Läuger
May 22, 1975·The Journal of Membrane Biology·D L Dorset, H M Fishman
Jan 1, 1985·Progress in Biophysics and Molecular Biology·H M Fishman
Jun 1, 1984·Journal of Neuroscience Methods·A S Finkel, S Redman
Jan 1, 1979·Brain Research Bulletin·I Tasaki
Apr 28, 1978·Annals of the New York Academy of Sciences·A M BrownK S Lee
Sep 25, 2003·Proceedings of the National Academy of Sciences of the United States of America·Robert K Adair
Apr 1, 1981·Pflügers Archiv : European journal of physiology·W Zeiske, W Van Driessche
Aug 15, 1977·Experientia·S AkselrodY Lass
May 8, 2015·Scientific Reports·Ying-Chih ChenYan-Kuin Su
May 21, 1982·Biochimica Et Biophysica Acta·W ZeiskeW Van Driessche
Jun 7, 1977·Journal of Theoretical Biology·R D Grisell
Oct 19, 1978·Nature·W Van Driessche, H Gögelein
Jul 27, 1978·Nature·N AkaikeA M Brown
Apr 21, 1984·Journal of Theoretical Biology·G Matsumoto

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