PMID: 9160540Jan 1, 1994Paper

Noise stress and the development of benzodiazepine dependence in the rat

Anxiety
S E File, C Fernandes

Abstract

Rats housed in conditions of noise stress were given daily injections of diazepam (4 mg/kg). Significant tolerance developed to the sedative effects within 5 days of treatment, as measured by head dipping and motor activity in the holeboard and by the number of closed arm entries in the plus-maze. These results are in agreement with other reports of rapid tolerance to sedative effects. However, in contrast to the usual finding of tolerance to anxiolytic actions after 2-3 weeks of treatment, in this study no tolerance developed after 23 days of treatment to diazepam's anxiolytic effects in the plus-maze. On withdrawal from the 23 days of diazepam treatment, there was no anxiogenic response in the plus-maze. Therefore, it seems that when chronic administration of diazepam is accompanied by chronic stress, tolerance does not occur to the anxiolytic effects, although it does develop to the sedative effects.

References

Jan 1, 1990·Neuroscience and Biobehavioral Reviews·S E File
Jan 1, 1985·Neuroscience and Biobehavioral Reviews·S E File
Jan 1, 1985·Psychopharmacology·D N Stephens, H H Schneider
Mar 1, 1984·Drug and Alcohol Dependence·D Ladewig
Nov 1, 1993·The British Journal of Psychiatry : the Journal of Mental Science·R Islam
Mar 1, 1993·Pharmacology, Biochemistry, and Behavior·D R MacKenzie-Taylor, R H Rech

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Citations

Nov 29, 2002·Human Psychopharmacology·Michel Bourin, Olivier Lambert
Oct 1, 1994·Pharmacology, Biochemistry, and Behavior·C FernandesS E File
Feb 1, 2005·Psychiatry and Clinical Neurosciences·Leonardo F FontenelleMarcio Versiani
Sep 17, 2010·Psychiatry·Nirit Soffer-Dudek, Golan Shahar
Sep 26, 2003·Psychosomatic Medicine·Adrienne Stauder, Mónika Kovács
Jan 4, 2001·Psychosomatic Medicine·M B Gregerson
Dec 22, 2004·Progress in Neuro-psychopharmacology & Biological Psychiatry·Eszter Majercsik, József Haller
Feb 15, 2015·Neuroscience Letters·S LakehayliA Tazi
Dec 7, 2013·Revista brasileira de psiquiatria : orgão oficial da Associação Brasileira de Psiquiatria, Asociación Psiquiátrica de la América Latina·Alline C CamposFrancisco S Guimarães

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