Noisy pressure support ventilation: a pilot study on a new assisted ventilation mode in experimental lung injury

Critical Care Medicine
Marcelo Gama de AbreuThea Koch

Abstract

To describe and evaluate the effects of the new noisy pressure support ventilation (noisy PSV) on lung physiologic variables. Crossover design with four modes of mechanical ventilation. Experimental research facility of a university hospital. A total of 12 pigs weighing 25.0-36.5 kg. Animals were anesthetized, the trachea was intubated, and lungs were ventilated with a mechanical ventilator (volume-controlled mode). Acute lung injury was then induced by surfactant depletion. Biphasic intermittent airway pressure/airway pressure release ventilation (BIPAP/APRV) was initiated, and anesthesia depth was decreased to allow spontaneous breathing. After that, each animal was ventilated with four different modes of assisted mechanical ventilation (1 hr each, Latin squares sequence): 1) PSV, 2) PSV combined with intermittent sighs (PSV + Sighs), 3) BIPAP/APRV + spontaneous breathing, and 4) noisy PSV with random variation of pressure support (normal distribution). The mean level of pressure support was set identical in all PSV forms. We found that noisy PSV increased tidal volume variability compared with PSV and PSV + Sighs (19% vs. 5% and 7%, respectively, p < .05) independently from the inspiratory effort; improved oxygenation and re...Continue Reading

Associated Clinical Trials

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Citations

Jun 25, 2013·Intensive Care Medicine·Marcelo Gama de Abreu, F Javier Belda
Sep 28, 2012·Journal of Clinical Monitoring and Computing·Katherine T MoorheadThomas Desaive
Jan 10, 2012·Current Opinion in Anaesthesiology·Marcelo Gama de AbreuPaolo Pelosi
Apr 24, 2008·Critical Care Medicine·Theodoros Vassilakopoulos, Spyros Zakynthinos
Dec 4, 2009·Current Opinion in Critical Care·Giorgio Conti, Roberta Costa
Mar 19, 2011·Current Opinion in Critical Care·Paolo PelosiMarcelo Gama de Abreu
Jan 10, 2012·Current Opinion in Critical Care·Onnen Moerer
Jan 20, 2009·American Journal of Respiratory and Critical Care Medicine·Peter M SpiethMarcelo Gama de Abreu
Nov 25, 2011·Critical Care : the Official Journal of the Critical Care Forum·Andreas W ReskeHermann Wrigge
Jun 22, 2012·Critical Care : the Official Journal of the Critical Care Forum·Nicolas TerziJean-Christophe Marie Richard
Jul 5, 2008·Critical Care : the Official Journal of the Critical Care Forum·John J Marini
Nov 5, 2008·Critical Care : the Official Journal of the Critical Care Forum·Dirk VarelmannHermann Wrigge
Mar 20, 2010·Critical Care : the Official Journal of the Critical Care Forum·Paolo PelosiPatricia R M Rocco
Mar 18, 2010·Critical Care : the Official Journal of the Critical Care Forum·Marcelo Gama de AbreuEdmund Koch
Aug 24, 2012·PloS One·Sarah M McMullenUNKNOWN Canadian Critical Care Trials Group (CCCTG)
Jan 25, 2014·Critical Care : the Official Journal of the Critical Care Forum·Lucia MirabellaJennifer Beck
Jul 28, 2010·Expert Review of Respiratory Medicine·Patricia R M RoccoMarcelo Gama de Abreu
Apr 10, 2014·Experimental Lung Research·Robert HuhleMarcelo Gama de Abreu
Dec 17, 2014·Journal of Burn Care & Research : Official Publication of the American Burn Association·David J Dries
Aug 21, 2012·Critical Care Medicine·Jérôme Allardet-Servent
Sep 8, 2012·Critical Care Research and Practice·Carmen Sílvia Valente BarbasCarlos Roberto Ribeiro Carvalho
Apr 17, 2015·Critical Care : the Official Journal of the Critical Care Forum·Matthieu SchmidtAlexandre Demoule
Mar 21, 2015·BMC Anesthesiology·Paolo Pelosi, Marcelo Gama de Abreu
Nov 1, 2013·Critical Care : the Official Journal of the Critical Care Forum·Peter M SpiethMarcelo Gama de Abreu
May 22, 2016·Intensive Care Medicine Experimental·Sumeet V JainNader M Habashi
Sep 25, 2017·Journal of Clinical Monitoring and Computing·Tobias BecherNorbert Weiler
Aug 17, 2017·PloS One·Ines RentzschMarcelo Gama de Abreu

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