PMID: 9556189Apr 29, 1998Paper

Nomenclature and state of the art on alpha1-adrenoceptors

European Urology
S Z Langer

Abstract

The concept of alpha1-adrenoceptor subtypes was first suggested in the mid 1980s on the basis of the different affinities of certain alpha1-adrenoceptor preparations for the alpha-adrenoceptor agonist, oxymetazoline, and the antagonists, WB4101 and phentolamine. Subsequent characterization of alpha1-adrenoceptors using radioligand binding and functional studies has led to the identification of three native prazosin high-affinity alpha1-adrenoceptor subtypes designated alpha1A, alpha1B and alpha1D, corresponding to the three alpha1-adrenoceptor subtypes (alpha1a, alpha1b and alpha1d) isolated by molecular cloning techniques. Since each of these three subtypes exhibits similar affinity for the selective alpha1-adrenoceptor antagonist, prazosin, [3H]prazosin can be used as a convenient probe to evaluate the interaction of compounds with these adrenoceptor subtypes. Considerable clinical experience over the last few years has provided convincing evidence to support the effectiveness of alpha1-adrenoceptor blockade in the treatment of bladder obstruction due to benign prostatic hyperplasia (BPH). The distribution of alpha1-adrenoceptors in the human prostate tissue has shown that the predominant cloned alpha1-adrenoceptor subtype ch...Continue Reading

Citations

Mar 21, 2008·Cell and Tissue Research·Daniel Barboza Cava QueirózMaria Christina W Avellar
Feb 17, 2000·The Annals of Pharmacotherapy·M Lee
Feb 4, 2005·Neurourology and Urodynamics·Sandra SigalaGiovanni Muzzonigro
Nov 11, 1999·European Journal of Pharmacology·M A SilvaC S Porto
Jul 9, 2004·Life Sciences·Fúlvio R MendesMaria Christina W Avellar

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