Nomogram based on albumin and neutrophil-to-lymphocyte ratio for predicting the prognosis of patients with oral cavity squamous cell carcinoma

Scientific Reports
Huang-Kai KaoKai-Ping Chang

Abstract

Increasing evidence indicates that inflammation plays a crucial role in cancer development. A novel scoring system based on albumin and the neutrophil-to-lymphocyte ratio (NLR) was developed and incorporated into a nomogram to create a more accurate prognostic tool for oral cavity squamous cell carcinoma (OSCC) patients. A retrospective review was performed on 613 consecutive patients undergoing ablative surgery for OSCC between September 2005 and December 2014. NLR and albumin were determined and used to calculate an albumin/NLR score (ANS). The nomogram was based on the ANS and several clinicopathological manifestations, and its accuracy was determined by the concordance index (c-index). A high ANS was significantly associated with aggressive tumor behaviors, such as T status, overall stage, extranodal extension, perineural invasion, tumor depth, and decreased overall survival (OS). Multivariate analysis indicated that age, overall stage, extranodal extension, and ANS were independent factors for OS. The c-index for OS prognosis was 0.750 using this nomogram compared to 0.688 using TNM staging alone. The prognostic accuracy for OS in OSCC patients can be significantly improved using a nomogram that incorporates the novel ANS ...Continue Reading

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Citations

Jun 12, 2020·JAMA Otolaryngology-- Head & Neck Surgery·Cristina ValeroSnehal G Patel
Oct 3, 2019·Journal of Gynecologic Oncology·Kosuke YoshidaFumitaka Kikkawa
Oct 30, 2020·Cancer Management and Research·Razan MansourMaysa Al-Hussaini
Nov 20, 2021·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Pierluigi MarianiLuigi Laino

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Methods Mentioned

BETA
surgical resection

Software Mentioned

SAS
R rms

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