Nomogram-derived prediction of pathologic complete response (pCR) in breast cancer patients treated with neoadjuvant chemotherapy (NCT).

BMC Cancer
Shengyu PuJian Zhang

Abstract

Previous research results on the predictive factors of neoadjuvant chemotherapy (NCT) efficacy in breast cancer are inconsistent, suggesting that the ability of a single factor to predict efficacy is insufficient. Combining multiple potential efficacy-related factors to build a model may improve the accuracy of prediction. This study intends to explore the clinical and biological factors in breast cancer patients receiving NCT and to establish a nomogram that can predict the pathologic complete response (pCR) rate of NCT. We selected 165 breast cancer patients receiving NCT from July 2017 to May 2019. Using pretreatment biopsy materials, immunohistochemical studies to assess estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER-2), and Ki-67 expression. The correlation between biological markers and pCR was analyzed. These predictors were used to develop a binary logistic regression model with cross-validation and to show the established predictive model with a nomogram. The nomogram for pCR based on lymphovascular invasion, anemia (hemoglobin≤120 g/L), ER, Ki67 expression levels and NCT regimen had good discrimination performance (area under the curve [AUC], 0.758; 95% confidence int...Continue Reading

References

Aug 15, 1998·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·B FisherH D Bear
Oct 3, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J ChangM Dowsett
Aug 30, 2000·Nature·C M PerouD Botstein
Oct 19, 2000·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M ColleoniA Goldhirsch
Feb 22, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·P M RavdinH L Parker
Mar 29, 2002·Medical Oncology·P VaupelM Hoeckel
May 9, 2003·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J-Y PiergaP Pouillart
Dec 9, 2003·The Breast : Official Journal of the European Society of Mastology·Keith N OgstonSteven D Heys
Oct 21, 2005·The New England Journal of Medicine·Martine J Piccart-GebhartUNKNOWN Herceptin Adjuvant (HERA) Trial Study Team
Oct 21, 2005·The New England Journal of Medicine·Edward H RomondNorman Wolmark
Nov 19, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Roman RouzierGabriel N Hortobagyi
Dec 27, 2005·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·A H S LeeR W Blamey
Aug 11, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Maria StendahlKarin Jirström
Apr 3, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Peter DubskyUNKNOWN Austrian Breast and Colorectal Cancer Study Group
May 1, 2008·Breast Cancer Research : BCR·Attila TordaiLajos Pusztai
Feb 11, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Judith HughCharles Vogel
Jun 25, 2010·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Takayoshi UematsuAkiko Ogiya
Oct 14, 2011·The New England Journal of Medicine·Dennis SlamonUNKNOWN Breast Cancer International Research Group
Jun 1, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Laura J EssermanNola Hylton
Aug 24, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·C DenkertG von Minckwitz
Feb 11, 2015·Annals of Surgical Oncology·Krishna B CloughPascal Bonnier
Sep 1, 2015·Annals of Oncology : Official Journal of the European Society for Medical Oncology·E SenkusUNKNOWN ESMO Guidelines Committee
Jan 4, 2017·Breast Cancer Research and Treatment·Isabel EchavarriaJose Angel García-Saenz
Mar 11, 2018·Journal of the National Comprehensive Cancer Network : JNCCN·William J GradisharDorothy A Shead
Oct 3, 2019·CA: a Cancer Journal for Clinicians·Carol E DeSantisRebecca L Siegel

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy

Software Mentioned

SPSS Statistics
R

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.