Nomogram for predicting the risk of local recurrence after breast-conserving surgery for ductal carcinoma in situ

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Udo RudloffKimberly J Van Zee

Abstract

While the mortality associated with ductal carcinoma in situ (DCIS) is minimal, the risk of ipsilateral breast tumor recurrence (IBTR) after breast-conserving surgery (BCS) is relatively high. Radiation therapy (RT) and antiestrogen agents reduce the risk of IBTR and are considered standard treatment options after BCS. However, they have never been proven to improve survival, and in themselves carry rare but serious risks. Individualized estimation of IBTR risk would assist in decision making regarding the various treatment options for women with DCIS. From 1991 to 2006, 1,868 consecutive patients treated with BCS for DCIS were identified. A multivariate Cox proportional hazards model was constructed using the 1,681 in whom data were complete. Ten clinical, pathologic, and treatment variables were built into a nomogram estimating probability of IBTR at 5 and 10 years after BCS. The model was validated for discrimination and calibration using bootstrap resampling. The DCIS nomogram for prediction of 5- and 10-year IBTR probabilities demonstrated good calibration and discrimination, with a concordance index of 0.704 (bootstrap corrected, 0.688) and a concordance probability estimate of 0.686. Factors with the greatest influence o...Continue Reading

References

Jan 1, 1992·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·M J SilversteinJ R Waisman
Mar 1, 1996·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·L J SolinM McNeese
Jun 1, 1996·Cancer·M J SilversteinD N Poller
Feb 20, 1998·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·B FisherM Kavanah
Apr 29, 1998·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M J SilversteinJ R Waisman
May 13, 1999·The New England Journal of Medicine·M J SilversteinW J Colburn
May 20, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M W KattanP T Scardino
Jan 19, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·F A ViciniA A Martinez
Mar 10, 2001·Journal of the National Cancer Institute·B RockhillG A Colditz
May 2, 2001·International Journal of Technology Assessment in Health Care·F E Harrell, Y C Shih
May 18, 2001·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·G Noël, J J Mazeron
Oct 17, 2002·Journal of the National Cancer Institute·Virginia L ErnsterBerta M Geller
Apr 26, 2003·Proceedings of the National Academy of Sciences of the United States of America·Xiao-Jun MaDennis C Sgroi
Sep 27, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Michael W KattanMurray F Brennan
Mar 18, 2004·Journal of the National Cancer Institute·Nancy N BaxterTodd M Tuttle
Jul 27, 2004·Annals of Surgery·Murray F BrennanKevin Conlon
Oct 12, 2004·American Journal of Surgery·Lina RomeroMelvin J Silverstein
Jul 16, 2005·Annals of Surgical Oncology·Michelle C SpechtKimberly J Van Zee
Sep 30, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Andrew J StephensonMichael W Kattan
Feb 7, 2006·Breast Cancer Research : BCR·Anjali S KumarI Craig Henderson
Feb 8, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Lawrence J Solin
Feb 8, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Julia S WongBarbara L Smith
Nov 23, 2006·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·A RingbergL Holmberg
Jun 20, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Tina W F YenJane C Weeks
Jun 21, 2007·American Journal of Clinical Pathology·Edwin R FisherNorman Wolmark
Aug 1, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·José Luiz B BevilacquaKimberly J Van Zee
Nov 7, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Eileen RakovitchLawrence Paszat
Nov 7, 2007·Nature Clinical Practice. Urology·Michael W Kattan, Peter T Scardino
Nov 13, 2007·Cancer Cell·Peter T SimpsonSunil R Lakhani

❮ Previous
Next ❯

Citations

Nov 1, 1988·Biochimie·W McDowell, R T Schwarz
Nov 21, 2012·Nature Reviews. Clinical Oncology·Philippe LambinAndre Dekker
Mar 24, 2012·Journal of the National Cancer Institute·Monica Morrow, Steven J Katz
Jun 12, 2012·International Journal of Surgical Oncology·Daniel Xavier Choi, Kimberly J Van Zee
Jan 19, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Min YiKelly K Hunt
Jun 27, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jeffrey M AlbertBenjamin D Smith
May 25, 2012·Annals of Surgical Oncology·Rosalinda AlvaradoHenry M Kuerer
Jan 30, 2014·Journal of Geriatric Oncology·Noam VanderWaldeHyman Muss
Aug 2, 2012·International Journal of Surgical Oncology·Richard J LeeJennifer L Peterson
Dec 7, 2013·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·R SouchonUNKNOWN Breast Cancer Expert Panel of the German Society of Radiation Oncology (DEGRO)
Feb 5, 2016·Breast Cancer Research and Treatment·Michael J HassettRinaa S Punglia
Mar 30, 2013·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·B CutuliR Fay
Mar 12, 2013·International Journal of Radiation Oncology, Biology, Physics·John J CoenWilliam U Shipley
Mar 8, 2013·The Surgical Clinics of North America·Richard J Bleicher
Jan 16, 2016·Histopathology·Jia-Min B PangStephen B Fox
Jun 5, 2012·Gynécologie, obstétrique & fertilité·P Romestaing
Nov 12, 2010·Canadian Association of Radiologists Journal = Journal L'Association Canadienne Des Radiologistes·Anabel M ScaraneloStefan O Hofer
Dec 31, 2015·Journal of the National Cancer Institute·Caroline S BennetteDavid L Veenstra
May 20, 2015·Annals of Surgical Oncology·Priya ParikhRichard Gray
Nov 26, 2015·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Ian GanlySnehal G Patel
Oct 3, 2015·CA: a Cancer Journal for Clinicians·Elizabeth M WardTed Gansler
Oct 16, 2015·International Journal of Radiation Oncology, Biology, Physics·Jean-Philippe PignolHelena A Verkooijen
Jul 2, 2011·Cancer·Rinaa S PungliaJane C Weeks
Nov 10, 2010·The Breast Journal·Shicha Kumar, Virgilio Sacchini
May 28, 2014·Journal of Surgical Oncology·Olga Kantor, David J Winchester
Mar 28, 2016·Academic Radiology·Habib RahbarChristoph I Lee
Jun 6, 2012·International Journal of Surgical Oncology·P OrsariaO Buonomo
Mar 26, 2014·International Journal of Radiation Oncology, Biology, Physics·Fuh Yong WongPuay Hoon Tan
Dec 17, 2014·The Breast Journal·Michael D Lagios, Melvin J Silverstein
Apr 8, 2015·The Lancet Oncology·Vinod P BalachandranRonald P DeMatteo

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