Nomogram prediction of survival in patients with brain metastases from hepatocellular carcinoma treated with whole-brain radiotherapy: a multicenter retrospective study

Journal of Neuro-oncology
Younghee ParkAh Ram Chang

Abstract

The incidence of brain metastasis from hepatocellular carcinoma (HCC) is increasing because of the improved survival outcome of HCC patients, but the prognosis of these patients is extremely poor. HCC patients with brain metastasis were investigated to identify their prognostic factors for overall survival. Patients with brain metastasis from HCC who had been treated with whole-brain radiotherapy (WBRT) in five hospitals were enrolled in the study. The medical records of the patients were reviewed, and the clinical factors were analyzed to identify the prognostic factors for overall survival. Of the total of 97 patients who were enrolled in the study, 83 were male and the median age at the brain metastases was 56.6 years. Motor weakness (43.3 %) and headache (41.2 %) were common presenting symptoms. The median AFP level was 4180 ng/ml, and 81 patients were assessed as belonging to Child-Pugh classification A upon the diagnosis of brain metastasis. WBRT alone in 71 patients, surgery or radiosurgery combined with WBRT as the adjuvant setting in 18 patients, and WBRT as salvage treatment in 8 patients were performed. The median overall survival of the patients was 3.5 months. In the multivariate analysis, the ECOG performance stat...Continue Reading

References

Feb 22, 1990·The New England Journal of Medicine·R A PatchellB Young
May 1, 1996·Neuroradiology·K MurakamiT Ichikawa
Mar 1, 1997·International Journal of Radiation Oncology, Biology, Physics·L GasparR Byhardt
Apr 3, 1998·Journal of Neuro-oncology·M KimJ K Roh
Mar 22, 2000·International Journal of Radiation Oncology, Biology, Physics·E WeltmanD B Wajsbrot
Jul 21, 2004·Surgical Neurology·Lin ChangMing-Chien Kao
Sep 1, 2004·International Journal of Radiation Oncology, Biology, Physics·José LorenzoniMarc Levivier
Oct 13, 2007·International Journal of Radiation Oncology, Biology, Physics·Paul W SperdutoWalter Curran
May 1, 2012·Neuro-oncology·Jill S Barnholtz-SloanMichael W Kattan
Jul 24, 2014·Journal of Neuro-oncology·Kyung Su KimSung W Ha

❮ Previous
Next ❯

Citations

May 7, 2019·Gut and Liver·UNKNOWN Korean Liver Cancer Association, UNKNOWN National Cancer Center
Mar 23, 2017·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Tackeun KimChae-Yong Kim
Jul 5, 2019·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·UNKNOWN Korean Liver Cancer Association (KLCA), UNKNOWN National Cancer Center (NCC), Goyang, Korea
Aug 10, 2021·World Journal of Clinical Cases·Hai-Yi LongBao-Xian Liu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Hepatocellular

Hepatocellular Carcinoma is a malignant cancer in liver epithelial cells. Discover the latest research on Hepatocellular Carcinoma here.