Nomograms for prognostication of outcome in patients with esophageal and gastroesophageal carcinoma undergoing definitive chemoradiotherapy

Oncology
Akihiro SuzukiJaffer A Ajani

Abstract

Level-1 evidence for definitive chemoradiotherapy (bimodality therapy or BM therapy) has been established for patients with esophageal and gastroesophageal junction cancers (EGEJC) who otherwise do not qualify for surgery; however, tools to estimate individual patient prognosis are unavailable. We used a number of clinical pre- and post-treatment parameters to establish two nomograms: for overall survival (OS) and relapse-free survival (RFS). From 2002 through 2010, 257 consecutive patients with EGEJC who received BM therapy and had pre- and post-treatment positron emission tomography (PET) and post-treatment endoscopic biopsies among other assessments were analyzed from a prospectively maintained database. Standard statistical methods were used to generate the nomograms. None of the 257 patients underwent surgery. Persistent or recurrent cancer was documented in 187 (72.8%) patients. The estimated median survival duration for all 257 patients was 21.1 months (95% CI, 18.9-27.1) and the median RFS duration was 11.6 months (95% CI, 9.43-15.0). After BM therapy, 155 (60.3%) patients achieved a clinical complete response (cCR). In multivariate analyses, maximum initial standardized uptake value and cCR were independent prognostic ...Continue Reading

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Citations

Jan 25, 2013·Nature Reviews. Cancer·Bram De Craene, Geert Berx
Nov 20, 2013·Nature Reviews. Endocrinology·Pierlorenzo PallanteAlfredo Fusco
Jun 5, 2014·BioMed Research International·Suning HuangGang Chen
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Feb 28, 2019·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Guillaume S ChevrollierAdam C Berger

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