Nomograms to predict the pathological stage of clinically localized prostate cancer in Korean men: comparison with western predictive tools using decision curve analysis

International Journal of Urology : Official Journal of the Japanese Urological Association
Chang Wook JeongSang Eun Lee

Abstract

To develop and evaluate nomograms to predict the pathological stage of clinically localized prostate cancer after radical prostatectomy in Korean men. We reviewed the medical records of 2041 patients who had clinical stages T1c-T3a prostate cancer and were treated solely with radical prostatectomy at two hospitals. Logistic regressions were carried out to predict organ-confined disease, extraprostatic extension, seminal vesicle invasion, and lymph node metastasis using preoperative variables and resulting nomograms. Internal validations were assessed using the area under the receiver operating characteristic curve and calibration plot, and then external validations were carried out on 129 patients from another hospital. Head-to-head comparisons with 2007 Partin tables and Cancer of the Prostate Risk Assessment score were carried out using the area under the curve and decision curve analysis. The significant predictors for organ-confined disease and extraprostatic extension were clinical stage, prostate-specific antigen, Gleason score and a percent positive core of biopsy. Significant predictors for seminal vesicle invasion were prostate-specific antigen, Gleason score and percent positive core, and those for lymph node metastas...Continue Reading

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Citations

May 31, 2013·Annals of Surgical Oncology·Kwang Hyun KimSung Joon Hong
Jun 18, 2014·PloS One·Minyong KangUNKNOWN Seoul National University-Uro-Oncology Group
Jun 17, 2016·International Journal of Urology : Official Journal of the Japanese Urological Association·Hyun Jung LeeSung-Woo Park
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Apr 9, 2019·Minerva urologica e nefrologica = The Italian journal of urology and nephrology·Ahmed EissaGiampaolo Bianchi

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