PMID: 6408224Jan 1, 1983Paper

Non-A, non-B hepatitis in chimpanzees: interference with acute hepatitis A virus and chronic hepatitis B virus infections

Journal of Medical Virology
D W BradleyJ W Ebert

Abstract

Two chimpanzees with persistent non-A, non-B (NANB) hepatitis were superinfected with marmoset-passaged MS-1 HAV. Two control chimpanzees were also infected with marmoset-passaged HAV. Neither animal with persistent NANB hepatitis developed elevated alanine aminotransferase (ALT) activity, whereas both control chimpanzees exhibited ALT elevations within 3 weeks after inoculation. In addition, both NANB-infected chimpanzees demonstrated a delayed anti-HAV antibody response in which one animal failed to produce detectable IgM anti-HAV. With the exception of one stool, all serial liver biopsy specimens and daily stool suspensions from the superinfected chimpanzees were negative for HAV antigen. One chimpanzee with a chronic HBV infection was superinfected with non-A, non-B hepatitis and was shown to develop elevated ALT activity and hepatocyte ultrastructural alterations accompanied by a marked reduction in the titer of serum HBsAg. Our combined findings indicate that acute and persistent non-A, non-B hepatitis infections are capable of interferring with two distinctly different hepatotropic viruses. These results also suggest that in vitro detection of non-A, non-B hepatitis infection or virus(es) may be achieved by antibody-inde...Continue Reading

Citations

Aug 1, 1994·Journal of Medical Virology·J F TsaiJ H Tsai
Jun 1, 1997·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·J CrespoF Pons-Romero
Nov 26, 2002·Journal of Hepatology·Christian G SchüttlerStephan Schaefer
Apr 16, 1998·Journal of Hepatology·J P ZarskiD Dhumeaux
Jan 4, 1998·Journal of Gastroenterology and Hepatology·S N HuangY F Liaw
Sep 16, 1998·Journal of Gastroenterology and Hepatology·G K LauS K Lam
Apr 10, 2008·Journal of Gastroenterology and Hepatology·Chi-Jen Chu, Shou-Dong Lee
Jan 11, 2012·Clinical Microbiology Reviews·Jasmine SamalPerumal Vivekanandan
Apr 15, 2006·International Journal of Medical Sciences·Zhihua Liu, Jinlin Hou
Jan 1, 1984·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·Z SchaffR J Gerety
Sep 11, 2012·Clinics and Research in Hepatology and Gastroenterology·Lamine HamzaouiMohamed Msaddak Azzouz
Dec 25, 2008·Gastroenterology·Stuart C Gordon, Kenneth E Sherman
Mar 17, 2010·International Journal of Cancer. Journal International Du Cancer·Lisa Y ChoSue K Park
Oct 13, 2006·Journal of Hepatology·Katja DeterdingHeiner Wedemeyer
May 1, 1984·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·K N TsiquayeA J Zuckerman
Jan 1, 1985·Journal of Hepatology·C A LeeH C Thomas
Jan 1, 1986·Journal of Hepatology·M RizzettoR H Purcell
Mar 26, 2004·Journal of Medical Virology·Bing-Fang ChenPei-Jer Chen
Jun 26, 2001·Journal of Gastroenterology and Hepatology·Y F Liaw
Dec 1, 1993·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·T J LiangE R Schiff
Nov 1, 1985·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·R H PurcellM E Hrinda
Oct 1, 1995·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Y F Liaw
Apr 1, 1995·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S L TsaiG C Kuo
Nov 1, 1989·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Y K Shimizu, R H Purcell
Jan 1, 1987·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A J Zuckerman
Dec 1, 1995·Haemophilia : the Official Journal of the World Federation of Hemophilia·G Dolan
Apr 1, 1993·Histopathology·R ColombariP J Scheuer
Apr 8, 2015·World Journal of Hepatology·Kyoungsub SongTong Wu
Oct 29, 2002·The Journal of Biological Chemistry·Shiow-Yi ChenYan-Hwa Wu Lee
Mar 13, 2020·The Journal of Clinical Investigation·Xiaoming ChengT Jake Liang
Jan 1, 1989·Scandinavian Journal of Infectious Diseases. Supplementum·L Mattsson
Oct 1, 1992·Gastroenterologia Japonica·T DoiT Tsuji
Nov 1, 1993·British Journal of Haematology·J P HanleyW L Irving
Sep 13, 2003·World Journal of Gastroenterology : WJG·Chun-Lei FanYu Wang

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