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Non-activatable mutant of inhibitor of kappa B kinase α (IKKα) exerts vascular site-specific effects on atherosclerosis in Apoe-deficient mice

Atherosclerosis

Nov 2, 2019

Pathricia Veronica TilstamHeidi Noels

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Abstract

IKKα is an important regulator of gene expression. As IKKα kinase inactivity in bone marrow-derived cells does not affect atherosclerosis, we here investigate the impact of a whole body-IKKα kinase inactivity on atherosclerosis. Apolipoprotein E (Apoe)-deficient mice homozygous for an a...read more

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Aorta
Aortic Arch Structure
Apolipoprotein E
Atherosclerosis
Structure of Brachiocephalic Artery
Collagen
Site-Specific DNA-Methyltransferase (Adenine-Specific)
Enzyme-Linked Immunosorbent Assay
Gene Expression
Macrophage
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Non-activatable mutant of inhibitor of kappa B kinase α (IKKα) exerts vascular site-specific effects on atherosclerosis in Apoe-deficient mice

Atherosclerosis

Nov 2, 2019

Pathricia Veronica TilstamHeidi Noels

PMID: 31733453

DOI: 10.1016/j.atherosclerosis.2019.10.023

Abstract

IKKα is an important regulator of gene expression. As IKKα kinase inactivity in bone marrow-derived cells does not affect atherosclerosis, we here investigate the impact of a whole body-IKKα kinase inactivity on atherosclerosis. Apolipoprotein E (Apoe)-deficient mice homozygous for an a...read more

Mentioned in this Paper

Aorta
Aortic Arch Structure
Apolipoprotein E
Atherosclerosis
Structure of Brachiocephalic Artery

Related Papers

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