Non-adjuvanted 2009 influenza A (H1N1)v vaccine in pregnant women: the results of a French prospective descriptive study

Vaccine
E OmonB Escourrou

Abstract

In 2009, during the influenza A (H1N1)v pandemic, the French Health authorities recommended influenza immunisation for pregnant women because of the higher risk of serious influenza outcomes in that population. Thus, the non-adjuvanted inactivated influenza vaccine Panenza(®) was administered to French women from the second trimester of pregnancy. Several studies suggest that inactivated seasonal influenza vaccines are safe during pregnancy but there are few data about the effects of new A (H1N1)vaccines (new antigen) on pregnant women. The aim of the present prospective study was to describe pregnancy outcomes among women vaccinated with non-adjuvanted influenza vaccines in South Western France. the study ran from November 2009 to February 2010 and included, on a voluntary basis, pregnant women who were vaccinated against A (H1N1) influenza in vaccination clinics or maternity wards. 569 pregnant women were monitored until delivery. Compared with the general population, the risks of maternal conditions, malformations and neonatal conditions were not statistically different. This study does not reveal any sign of safety concerns regarding the effects of the vaccine on pregnancy outcomes.

References

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Citations

Jul 13, 2014·Human Reproduction Update·Azure N FaucetteKang Chen
May 3, 2013·Obstetrics and Gynecology·Ava Marie S ConlinNancy F Crum-Cianflone
Feb 3, 2012·Maternal and Child Health Journal·Marie TarrantVincci Hiu Sze Chan
Sep 26, 2012·Expert Review of Vaccines·Pedro L MoroKaren Broder
May 28, 2015·Acta Obstetricia Et Gynecologica Scandinavica·Wouter J MeijerAnnemarie M J Wensing
Sep 7, 2012·American Journal of Obstetrics and Gynecology·Robert BednarczykSaad B Omer
Feb 25, 2015·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Satoshi TakedaKoushi Yamaguchi
Jun 2, 2016·Human Vaccines & Immunotherapeutics·Jennifer A BeelerSaad B Omer
Aug 20, 2016·Human Vaccines & Immunotherapeutics·Annette K Regan
Feb 2, 2018·The Cochrane Database of Systematic Reviews·Vittorio DemicheliCarlo Di Pietrantonj
May 30, 2013·European Journal of Epidemiology·Jonas F LudvigssonOlof Stephansson
Mar 14, 2014·The Cochrane Database of Systematic Reviews·Vittorio DemicheliCarlo Di Pietrantonj
Aug 6, 2019·Frontiers in Medicine·Carla TorreAna Paula Martins
Aug 21, 2012·BJOG : an International Journal of Obstetrics and Gynaecology·B Källén, P O Olausson

Related Concepts

panenza vaccine
Influenza
Trivalent Live Attenuated Influenza Vaccine
Pregnancy Outcome
Pregnant Women
Influenza A Virus, H1N1 Subtype
Antigens
Influenza virus vaccine
Influenza A virus
Vaccination

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