Non-albicans Candida prosthetic joint infections: A systematic review of treatment

World Journal of Clinical Cases
Christos KoutserimpasGeorge Samonis

Abstract

Non-albicans Candida prosthetic joint infections (PJIs) are rare. Optimal treatment involves a two-stage revision surgery in combination with an antifungal agent. However, no clear guidelines have been developed regarding the agent or treatment duration. Hence, a broad range of antifungal and surgical treatments have been reported so far. To clarify treatment of non-albicans Candida PJIs. A literature review of all existing non-albicans Candida PJIs cases through April 2018 was conducted. Information was extracted about demographics, comorbidities, responsible species, duration and type of antifungal treatment, type of surgical treatment, time between initial arthroplasty and symptom onset, time between symptom onset and definite diagnosis, outcome of the infection and follow-up. A total of 83 cases, with a mean age of 66.3 years, were located. The causative yeast isolated in most cases was C. parapsilosis (45 cases; 54.2%), followed by C. glabrata (18 cases; 21.7%). The mean Charlson comorbidity index was 4.4 ± 1.5. The mean time from arthropalsty to symptom onset was 27.2 ± 43 mo, while the mean time from symptom onset to culture-confirmed diagnosis was 7.5 ± 12.5 mo. A two stage revision arthroplasty (TSRA), when compared to...Continue Reading

References

Sep 1, 1992·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·J PaulD W Crook
Jan 1, 1989·Reviews of Infectious Diseases·R O DarouicheR L Harris
Sep 1, 1988·Reviews of Infectious Diseases·M LambertusM B Goetz
Jan 1, 1983·Skeletal Radiology·E A Lichtman
Apr 1, 1995·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·A White, M B Goetz
Jan 1, 1993·The American Journal of Medicine·A R TunkelB Wispelwey
Mar 11, 1998·The Journal of Arthroplasty·G P SelmonE P Wright
Jan 1, 1997·Scandinavian Journal of Infectious Diseases·F NayeriC Söderström
Jun 30, 1998·The Journal of Arthroplasty·M WadaS Imura
Sep 19, 1998·The Journal of Arthroplasty·D H Brooks, F Pupparo
Mar 13, 2001·The Journal of Infection·N RamamohanI Butcher
Jun 13, 2001·The Journal of Arthroplasty·S H YangY S Hang
Jun 19, 2002·Scandinavian Journal of Infectious Diseases·Z Cibali AçikgözSöhret Gamberzade
Oct 16, 2004·The Journal of Arthroplasty·Glenn Gaston, John Ogden
Mar 2, 2005·International Journal of Antimicrobial Agents·T Lejko-ZupancF Vrevc
Feb 5, 2008·International Journal of Antimicrobial Agents·V DumaineD Salmon
Apr 19, 2008·Clinical Orthopaedics and Related Research·Luis PulidoJavad Parvizi
Oct 16, 2008·Clinical Microbiology Reviews·David TrofaJoshua D Nosanchuk
Nov 26, 2009·The Journal of Bone and Joint Surgery. American Volume·Khalid AzzamRobert Barrack
Jul 9, 2010·Scandinavian Journal of Infectious Diseases·Herve DutroncMichel Dupon
Jul 15, 2011·The Journal of Arthroplasty·Konstantinos AnagnostakosJochen Jung
Apr 25, 2012·The Journal of Bone and Joint Surgery. British Volume·B H HwangS H Moon
Sep 26, 2012·BMJ Case Reports·Rebecca Louise HallHasnat Minhas
May 2, 2013·Clinical Orthopaedics and Related Research·Steve W N UengYuhan Chang
May 31, 2013·Journal of the Royal Army Medical Corps·Surjit LidderR W J Carrington
Oct 18, 2013·Indian Journal of Orthopaedics·Kankanala J ReddyT Jayakrishna Reddy
Jan 8, 2014·Experimental and Therapeutic Medicine·Yun ZhuFuxing Pei
May 8, 2014·International Journal of Microbiology·Sachin C DeorukhkarStephen Mathew
Feb 14, 2015·Orthopaedics & Traumatology, Surgery & Research : OTSR·Q-J WangJ-J Shao
Apr 16, 2015·Orthopedic Reviews·Benjamin SchoofMatthias Gebauer
Jun 3, 2015·Mycoses·Maurizio SanguinettiCornelia Lass-Flörl
Jan 27, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Peter G PappasJack D Sobel
Jun 14, 2018·JAMA : the Journal of the American Medical Association·Björn PasternakOlof Stephansson

❮ Previous
Next ❯

Citations

Oct 1, 2019·Case Reports in Orthopedics·Samuel S OrnellAnil K Dutta
Jan 30, 2021·JBJS Case Connector·Mário BaptistaCarlos Mateus
Dec 4, 2020·The Journal of Arthroplasty·Christopher E GrossElizabeth C Durante
Aug 28, 2021·Diagnostics·Christos KoutserimpasGeorge Samonis

❮ Previous
Next ❯

Methods Mentioned

BETA
amputation

Software Mentioned

Excel

Related Concepts

Related Feeds

Candidiasis

Candidiasis is a common fungal infection caused by Candida and it can affect many parts for the body including mucosal membranes as well as the gastrointestinal, urinary, and respiratory tracts. Here is the latest research.

Candidiasis (ASM)

Candidiasis is a common fungal infection caused by Candida and it can affect many parts for the body including mucosal membranes as well as the gastrointestinal, urinary, and respiratory tracts. Here is the latest research.

Candida albicans

Candida albicans is an opportunistic, fungal pathogen of humans that frequently causes superficial infections of oral and vaginal mucosal surfaces of debilitated and susceptible individuals. Discover the latest research on Candida albicans here.