Non-albuminuric renal impairment is a strong predictor of mortality in individuals with type 2 diabetes: the Renal Insufficiency And Cardiovascular Events (RIACE) Italian multicentre study

Diabetologia
G PennoRenal Insufficiency And Cardiovascular Events (RIACE) Study Group

Abstract

Non-albuminuric renal impairment has become the prevailing diabetic kidney disease (DKD) phenotype in individuals with type 2 diabetes and an estimated GFR (eGFR) <60 ml min-1 1.73 m-2. In the present study, we compared the rate and determinants of all-cause death in individuals with this phenotype with those in individuals with albuminuric phenotypes. This observational prospective cohort study enrolled 15,773 individuals with type 2 diabetes in 2006-2008. Based on baseline albuminuria and eGFR, individuals were classified as having: no DKD (Alb-/eGFR-), albuminuria alone (Alb+/eGFR-), reduced eGFR alone (Alb-/eGFR+), or both albuminuria and reduced eGFR (Alb+/eGFR+). Vital status on 31 October 2015 was retrieved for 15,656 individuals (99.26%). Mortality risk adjusted for confounders was lowest for Alb-/eGFR- (reference category) and highest for Alb+/eGFR+ (HR 2.08 [95% CI 1.88, 2.30]), with similar values for Alb+/eGFR- (1.45 [1.33, 1.58]) and Alb-/eGFR+ (1.58 [1.43, 1.75]). Similar results were obtained when individuals were stratified by sex, age (except in the lowest age category) and prior cardiovascular disease. In normoalbuminuric individuals with eGFR <45 ml min-1 1.73 m-2, especially with low albuminuria (10-29 mg/da...Continue Reading

Associated Clinical Trials

Jul 15, 2008·Giuseppe Pugliese

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Citations

Apr 19, 2019·Diabetes/metabolism Research and Reviews·Federica BaruttaGabriella Gruden
Apr 27, 2019·BMC Medicine·Anna SoliniUNKNOWN Renal Insufficiency And Cardiovascular Events (RIACE) Study Group
Jul 16, 2020·BMJ Open Diabetes Research & Care·Giuseppe PennoUNKNOWN Renal Insufficiency And Cardiovascular Events (RIACE) Study Group
Jun 18, 2020·International Journal of Molecular Sciences·Daiji KawanamiMakito Tanabe
Dec 12, 2019·Frontiers in Cardiovascular Medicine·Rachel E ClimieRosa Maria Bruno
Sep 8, 2018·International Journal of Molecular Sciences·Mitchell J Hadden, Andrew Advani
Nov 27, 2020·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·Salvatore Di PaoloUNKNOWN Italian Society of Nephrology and the Italian Diabetes Society
Feb 1, 2021·Cardiovascular Diabetology·Emanuela OrsiUNKNOWN Renal Insufficiency And Cardiovascular Events (RIACE) Study Group
Feb 12, 2021·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·Yuwei YangJiafu Feng
Oct 31, 2020·Frontiers in Physiology·Qian FengJiafu Feng
Jun 5, 2021·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·Procolo Di BonitoUNKNOWN “The DIAbetic kidney disease in youth with type 1 diabetes in ITALY” (DIANITALY) Study Group
Jun 3, 2021·Journal of Clinical Medicine·Sheila González-SalvatierraBeatriz García-Fontana
Jun 3, 2021·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·Enzo BonoraUNKNOWN under the mandate of the Italian Diabetes Society
Nov 13, 2021·Frontiers in Endocrinology·Dong-Yuan ChangMing-Hui Zhao

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