Non-alcoholic fatty liver disease - histological scoring systems: a large cohort single-center, evaluation study

APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica
Archana RastogiShiv Sarin

Abstract

Non-alcoholic fatty liver disease (NAFLD) is an increasingly common cause of chronic liver disease. Till date, liver biopsy remains the gold standard for identification and quantification of the wide histological spectra of NAFLD. Histological scorings are very useful and widely applied for the diagnosis and management in clinical trials and follow-up studies of non-alcoholic steatohepatitis (NASH). However, in view of scarce published literature, there is a need to evaluate them in large cohort of NAFLD. This study was aimed to evaluate the two histological scoring systems (NAS-CRN, SAF) in the diagnosis of NAFLD and to assess the role of histological characteristics as injury markers in NAFLD. Retrospective histological study of liver biopsies of 1000 patients diagnosed as NAFLD, between 2010 and 2016, was conducted. Histopathologic evaluation and semiquantiative scoring based on NAS-CRN and SAF algorithm and their correlation with serum aminotransferase and fibrosis were performed. Liver biopsies were classified according to the NAS-CRN scoring, as NAS <3 (not NASH) in 72 (7.2%), NAS 3-4 (borderline NASH) in 310 (31%), and NAS ≥5 (definite NASH) in 618 (61.8%), and SAF classified 117 (11.7%) not NASH and 883 (88.3%) definite...Continue Reading

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Citations

May 29, 2020·Journal of Pathology and Translational Medicine·Kyoungbun LeeSo-Young Jin
Mar 11, 2020·Surgical Endoscopy·Mohamed Abdalla SalmanAhmed Abdallah Salman
Jan 21, 2021·Trends in Pharmacological Sciences·Ivana Semova, Sudha B Biddinger
Aug 14, 2020·Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery·Sébastien FreyAntonio Iannelli
Jul 31, 2021·Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery·Christopher J TignanelliSayeed Ikramuddin
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Sep 12, 2021·Scientific Reports·Lorena PantanoKathleen E Corey
Oct 16, 2021·The Journal of Clinical Investigation·Bin LiuYan Lu

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