Non-alcoholic fatty liver disease: a multicentre clinical study by the Italian Association for the Study of the Liver

Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
C LoguercioItalian AISF Clinical Group

Abstract

To define the characteristics of the Italian patient presenting non-alcoholic fatty liver disease. A total of 305 patients with abnormally high plasma aminotransferase and/or gamma-glutamyl-transpeptidase levels for at least 12 months, with no known cause of chronic liver damage, were consecutively enrolled in the study. Clinical, routine biochemical and liver histology investigations were carried out in all patients. Also evaluated were: (a) oral glucose load; (b) insulinaemia and insulin-resistance using the HOMA test model; and (c) plasma endotoxaemia, total antioxidant plasma capability, tumour necrosis factor-alpha, plasma interleukin-6 and -10 levels. Malondialdehyde and 4-hydroxynonenal content were determined on liver samples from 120 patients. The majority of patients were young overweight or obese males, with dyslipidaemia (20-60%), diabetes (10.5%), hyperinsulinaemia (40%), hyperferritinaemia (35%). Endotoxaemia was negative in all patients and cytokines were only sporadically altered. Total antioxidant plasma capability was decreased in 38.4% of the patients. Eighty percent of the cases had histological steatosis with a mild degree of inflammation and fibrosis. Seven patients had cirrhosis. Lipid peroxidation marker...Continue Reading

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Citations

Sep 1, 2007·Hepatology International·David van der Poorten, Jacob George
Dec 27, 2005·Comparative Hepatology·Thierry PoynardJanice Albrecht
Sep 29, 2011·World Journal of Hepatology·Hüseyin Saadettin UslusoyMacit Gülten
Dec 18, 2013·Seminars in Immunopathology·Kento ImajoAtsushi Nakajima
Apr 6, 2007·Digestive Diseases and Sciences·Carmela LoguercioUNKNOWN Real Sud Group
May 28, 2011·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Carmela LoguercioPiero Portincasa
Jul 3, 2007·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·C LoguercioT Stroffolini
Jan 5, 2008·European Journal of Clinical Investigation·P PortincasaG Calamita
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