Non-alcoholic fatty liver disease: An update with special focus on the role of gut microbiota

Metabolism: Clinical and Experimental
Michael DoulberisPanagiotis Katsinelos

Abstract

Non-alcoholic fatty liver disease (NAFLD) is a significant global health burden in children, adolescents and adults with substantial rise in prevalence over the last decades. Accumulating data from manifold studies support the idea of NAFLD as a hepatic manifestation of metabolic syndrome, being rather a systemic metabolic disease than a liver confined pathology. Emerging data support that the gut microbiome represents a significant environmental factor contributing to NAFLD development and progression. Apart from other regimens, probiotics may have a positive role in the management of NAFLD through a plethora of possible mechanisms. The current review focuses on the NAFLD multifactorial pathogenesis, including mainly the role of intestinal microbiome and all relevant issues are raised. Furthermore, the clinical manifestations and appropriate diagnostic approach of the disease are discussed, with all possible therapeutic measures that can be taken, also including the potential beneficial effect of probiotics.

Citations

Aug 3, 2017·Children·Marco PoetaPietro Vajro
May 22, 2018·Critical Reviews in Food Science and Nutrition·Liang Shen, Hong-Fang Ji
Sep 12, 2018·Helicobacter·Danute Ražuka-EbelaFrancesco Franceschi
Apr 4, 2018·Journal of Clinical Biochemistry and Nutrition·Toshio Kobayashi, Akira Andoh
Sep 2, 2017·Current Opinion in Clinical Nutrition and Metabolic Care·Marina Romaní-PérezYolanda Sanz
Apr 21, 2018·Evidence-based Complementary and Alternative Medicine : ECAM·Shu LiangQinhe Yang
Jun 3, 2018·Hormones : International Journal of Endocrinology and Metabolism·Charikleia StefanakiGeorge P Chrousos
Aug 6, 2019·The Journal of Toxicological Sciences·Sosuke MasudaToshinori Yoshida
Jun 20, 2018·The American Journal of Gastroenterology·Ronald L Koretz
May 30, 2019·Medicina·Anna Jeznach-SteinhagenAlina Kuryłowicz
Aug 21, 2019·Frontiers in Endocrinology·Ebe D'AdamoValerio Nobili
Sep 20, 2018·Medical Sciences : Open Access Journal·Peter Christopher KonturekYurdaguel Zopf
Mar 10, 2020·Canadian Journal of Gastroenterology & Hepatology·Akinjide Moses AkinnugaAndile Khathi
Sep 30, 2020·International Journal of Clinical Practice·Michael DoulberisStergios A Polyzos
Aug 17, 2020·Medical Hypotheses·Jannis KountourasMichael Doulberis
Sep 29, 2019·Annals of Hepatology· Guohong-Liu Hongyun-Wei
Jan 21, 2021·American Journal of Physiology. Gastrointestinal and Liver Physiology·Alexandre VillardRamaroson Andriantsitohaina
Mar 12, 2021·The Journal of Nutritional Biochemistry·Shumin SunHiroaki Oda
Jul 13, 2021·Journal of Agricultural and Food Chemistry·Chenyu XueJiali Wang
Feb 26, 2019·Journal of Agricultural and Food Chemistry·Yizhe CuiChuang Xu

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