Non-Alcoholic Fatty Liver Disease and Its Association with Depression in Korean General Population

Journal of Korean Medical Science
Ju Young JungJae-Hong Ryoo

Abstract

Recent studies have indicated the significant association between non-alcoholic fatty liver disease (NAFLD) and depression. However, there is ongoing debate on whether the risk for depression is actually related with the presence and severity of NAFLD. Thus, this study was conducted to investigate the association between depression and NAFLD evaluated by diverse modalities. A total of 112,797 participants from the Korean general population were enrolled. The study participants were categorized into three groups according to degree of NAFLD evaluated by ultrasonography, fatty liver index (FLI) and fibrosis-4 score (FIB-4). Depression was defined as a score of Center for Epidemiological Studies-Depression (CES-D) ≥ 16, and the odd ratios (ORs) and 95% confidence interval (CI) for depression (adjusted ORs [95% CI]) were assessed by multiple logistic regression analyses. In the unadjusted model, the presence and severity of NAFLD was not significantly associated with depressive symptoms. However, in the fully adjusted model, ORs for depression increased in proportion to the degree of ultrasonographically detected NAFLD (mild fatty liver: 1.14 [1.06-1.22]; and moderate to severe fatty liver: 1.32 [1.17-1.48]). An association was als...Continue Reading

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Citations

Oct 22, 2020·Life·Jessica BinettiTeresa Auguet
Feb 5, 2021·Frontiers in Medicine·Ji Min ChoiJeong Yoon Yim
Feb 5, 2021·Gastroenterology Nursing : the Official Journal of the Society of Gastroenterology Nurses and Associates·Yinji LiangChenli Lin
Mar 13, 2021·Epidemiology and Psychiatric Sciences·In Young ChoSeungho Ryu
Feb 24, 2021·The British Journal of Nutrition·Yinji LiangChenli Lin
Aug 4, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Baoying WangErping Xu

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