Abstract
Non-alcoholic fatty liver disease (NAFLD) has been recently identified as a risk factor of gastrointestinal tract cancers, especially hepatocellular carcinoma, and colorectal cancer. Whether NAFLD is a risk factor for cholangiocarcinoma (CCA) remains inconclusive. The aim of this study is to determine a potential association between NAFLD and CCA, stratifying by its subtypes; intrahepatic CCA (iCCA), and extrahepatic CCA (eCCA). A search was conducted for relevant studies published up to April 2017 using MEDLINE, EMBASE, Scopus and Cochrane databases. Odds ratio (OR) and adjusted OR with 95% confidence interval (CI) were estimated using a random-effects model. Subgroup analyses were conducted with study characteristics. Seven case-control studies were included in the analysis, with a total of 9,102 CCA patients (5,067 iCCA and 4,035 eCCA) and 129,111 controls. Overall, NAFLD was associated with an increased risk for CCA, with pooled OR of 1.95 (95%CI: 1.36-2.79, I 2 =76%). When classified by subtypes, NAFLD was associated with both iCCA and eCCA, with ORs of 2.22 (95%CI: 1.52-3.24, I 2 =67%) and 1.55 (95%CI: 1.03-2.33, I 2 =69%), respectively. The overall pooled adjusted ORs were 1.97 (95%CI: 1.41-2.75, I 2 =71%), 2.09 (95%CI, ...Continue Reading
References
Feb 24, 2001·Gastroenterology·M JaiswalG J Gores
Feb 24, 2004·American Journal of Physiology. Gastrointestinal and Liver Physiology·Norihisa IshimuraGregory J Gores
Jul 14, 2005·Gastroenterology·Leon A AdamsPaul Angulo
Nov 3, 2006·Cancer Research·Hania WehbeTushar Patel
Aug 11, 2007·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Tania M WelzelKatherine A McGlynn
Jan 8, 2008·The American Journal of Gastroenterology·Christine Carter-KentAriel E Feldstein
Jul 22, 2009·PLoS Medicine·David MoherUNKNOWN PRISMA Group
Jun 1, 2011·Alimentary Pharmacology & Therapeutics·G VernonZ M Younossi
Oct 12, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Roongruedee ChaiteerakijLewis R Roberts
Jul 31, 2013·PloS One·Jeffrey S ChangLi-Tzong Chen
Dec 7, 2013·Cancer Research·Rachel V GuestStuart J Forbes
Feb 11, 2014·Digestive Diseases and Sciences·Iliana DoychevaDouglas G Adler
Jun 14, 2014·Liver International : Official Journal of the International Association for the Study of the Liver·Ban Seok LeeJaehoon Roh
Jul 1, 2014·Cancers·Isao OkazakiYutaka Inagaki
Sep 16, 2014·Journal of Hepatology·Chiara RaggiJesper B Andersen
Oct 8, 2014·PloS One·Yanqiong LiuShan Li
Aug 15, 2015·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Zobair M YounossiSharon Hunt
Jan 1, 2016·Annals of Surgical Oncology·Andrea RuzzenenteAlfredo Guglielmi
Jan 17, 2016·Cancer Epidemiology·Magdalena StepienMazda Jenab
Mar 5, 2016·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jonggi ChoiLewis R Roberts
Mar 22, 2016·Journal of Surgical Oncology·Masahiko KinoshitaToshihiko Shibata
Apr 12, 2016·Clinics in Liver Disease·Mehmet SayinerZobair M Younossi
Apr 21, 2016·Nature Reviews. Gastroenterology & Hepatology·Jesus M BanalesDomenico Alvaro
May 18, 2016·International Journal of Molecular Sciences·Claudia SannaElisabetta Bugianesi
Sep 18, 2016·Journal of Gastroenterology·Wai-Kay Seto, Man-Fung Yuen
Dec 31, 2016·Oncotarget·Yan-Jiun HuangYun Yen
Citations
Aug 14, 2018·Cancer Science·Mami TakahashiHitoshi Nakagama
Mar 10, 2019·Liver International : Official Journal of the International Association for the Study of the Liver·Shahid A KhanGiovanni Brandi
Mar 30, 2019·Asian Journal of Endoscopic Surgery·Masahiko KinoshitaShoji Kubo
Sep 5, 2019·The American Journal of Tropical Medicine and Hygiene·Apisit ChaideeSomchai Pinlaor
Jan 25, 2020·PloS One·Jung-Min LeeSeung-Hyun Ko
Mar 5, 2020·Cancer·Andrea A FlorioJessica L Petrick
Jul 14, 2019·Gut·Nicole PriorMeritxell Huch
Jan 11, 2020·Gut·Cyril SobolewskiMichelangelo Foti
Jan 29, 2020·Expert Opinion on Investigational Drugs·Luke V SelbyTimothy M Pawlik
Mar 2, 2019·BMC Cancer·Peter L LabibStephen P Pereira
Jul 2, 2020·Nature Reviews. Gastroenterology & Hepatology·Jesus M BanalesGregory J Gores
Aug 5, 2020·Journal of Gastroenterology·Changqing XieJianyang Fu
Jun 2, 2020·Lipids in Health and Disease·Shou-Sheng LiuYong-Ning Xin
Nov 2, 2019·Nature Reviews. Gastroenterology & Hepatology·Letizia SatrianoJesper B Andersen
Feb 25, 2020·European Journal of Gastroenterology & Hepatology·Salvatore CorraoChristiano Argano
Dec 17, 2020·Journal of Diabetes and Its Complications·Rebecca Baqiyyah N ConwayWilliam J Blot
Jan 20, 2021·Diabetes, Obesity & Metabolism·Bertrand CariouArun J Sanyal
Nov 4, 2020·Cancers·Stefania De LorenzoGiovanni Brandi
Feb 4, 2021·Current Problems in Surgery·T Peter KinghamMichael I D'Angelica
Feb 9, 2021·Clinical Liver Disease·Kara WegermannAnna Mae Diehl
Feb 25, 2021·Expert Opinion on Investigational Drugs·Massimiliano CadamuroLuca Fabris
Nov 22, 2020·Canadian Journal of Diabetes·Charupong SaengboonmeeSopit Wongkham
Mar 14, 2021·Scientific Reports·Kyohei YugawaMasaki Mori
Apr 24, 2021·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Joo-Hyun ParkJoo Kyung Park
May 9, 2021·Journal of Hepatology·Jeongeun HyunAnna Mae Diehl
May 28, 2021·World Journal of Gastrointestinal Oncology·Gianluca RompianesiRoberto Troisi
May 31, 2021·Journal of Hepato-biliary-pancreatic Sciences·Soravis OsataphanCharupong Saengboonmee
Jul 25, 2021·International Journal of Molecular Sciences·Tingting ShiTsutomu Masaki
Apr 4, 2021·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Tracey G SimonJonas F Ludvigsson
Aug 24, 2021·Expert Review of Gastroenterology & Hepatology·Michele GhidiniAlice Indini
Aug 28, 2021·Cells·Tianhao ZhouLindsey Kennedy
Sep 18, 2021·United European Gastroenterology Journal·Nina Barner-RasmussenMartti Färkkilä
Nov 19, 2021·Seminars in Liver Disease·Massimiliano CadamuroLuca Fabris