Non-alcoholic Fatty Liver Disease: East Versus West

Journal of Clinical and Experimental Hepatology
Swastik Agrawal, Ajay K Duseja

Abstract

Non-alcoholic fatty liver disease (NAFLD) is an important cause of liver disease worldwide with prevalence ranging from 10% to 30% in various countries. It has become an important cause of unexplained rise in transaminases, cryptogenic cirrhosis, and cryptogenic hepatocellular carcinoma. Pathogenesis is related to obesity, insulin resistance, oxidative stress, lipotoxicity, and resultant inflammation in the liver progressing to fibrosis. Pharmacological treatment in patients with NAFLD is still evolving and the treatment of these patients rests upon lifestyle modification with diet and exercise being the cornerstones of therapy. While there are many similarities between patients with NAFLD from Asia and the West, there are certain features which make the patients with NAFLD from Asia stand apart. This review highlights the data on NAFLD from Asia comparing it with the data from the West.

Citations

May 11, 2019·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Louise Johanna Maria AlferinkSarwa Darwish Murad
Oct 17, 2017·Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology·Uday C GhoshalGourdas Choudhuri
Apr 13, 2016·Hepatology, Medicine and Policy·Jeffrey V Lazarus
Jun 4, 2015·Arquivos De Gastroenterologia·Consuêlo Padilha VilarCibelle Padilha Vilar Barreto
May 17, 2017·Journal of Clinical and Translational Hepatology·Sital SinghSouvik Sarkar

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