Non-alcoholic Fatty Liver Disease in Morbidly Obese Individuals Undergoing Bariatric Surgery: Prevalence and Effect of the Pre-Bariatric Very Low Calorie Diet

Obesity Surgery
Katherine J P SchwengerJohane P Allard

Abstract

Non-alcoholic fatty liver disease (NAFLD) affects 75 to 100% of the patients undergoing bariatric surgery (BSx), with non-alcoholic steatohepatitis (NASH) being present in 24 to 98% of the patients. We do not know whether these rates were before or after a very low calorie diet (VLCD) often prescribed before laparoscopic BSx and what is the prevalence of NAFLD post-VLCD. The purpose of this study is to determine the prevalence of simple steatosis (SS) and NASH in obese individuals undergoing BSx post-VLCD and assess biochemical markers pre- and post-VLCD in a subgroup of patients. One hundred and thirty-nine patients undergoing BSx at a single Canadian bariatric program had biochemical and clinical variables collected pre-VLCD. In 21 patients, biochemical measurements were repeated post-VLCD. During BSx, a wedged liver biopsy was performed in all patients and histology was reported as normal liver (NL), SS, or NASH. NAFLD was diagnosed in 76.3% of the BSx patients with 61.9% having SS and 14.4% having NASH; 23.7% had NL. Those with NASH had significantly higher (p < 0.05) pre-VLCD ALT, AST, insulin resistance, and proportion of individuals with diabetes compared to those with NL. Overall, VLCD resulted in significant decreases ...Continue Reading

References

Mar 1, 1991·Journal of Hepatology·T AndersenP Christoffersen
Sep 1, 1982·The Proceedings of the Nutrition Society·M D Bastow
Sep 1, 1995·Applied and Environmental Microbiology·W E Moore, L H Moore
May 1, 1993·Metabolism: Clinical and Experimental·J G KralJ Wang
Sep 14, 1999·The American Journal of Gastroenterology·E M BruntB R Bacon
Jul 26, 2002·Pediatrics International : Official Journal of the Japan Pediatric Society·Mukadder Ayşe SelimogluRasit Vural Yagci
Mar 20, 2003·Current Diabetes Reports·Jeanne M Clark, Anna Mae Diehl
Sep 10, 2003·American Journal of Physiology. Endocrinology and Metabolism·David E KelleySatish C Kalhan
Nov 6, 2004·Obesity Surgery·Robert J Fris
Nov 27, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jeffrey D BrowningHelen H Hobbs
Mar 30, 2005·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Leon A AdamsKeith D Lindor
May 17, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Giorgio BedogniStefano Bellentani
Jan 19, 2006·International Journal of Obesity : Journal of the International Association for the Study of Obesity·K H LiuW L Kong
Aug 11, 2006·Journal of Hepatology·Mariana MachadoHelena Cortez-Pinto
Nov 30, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Elisabetta BugianesiJacob George
Aug 24, 2007·The New England Journal of Medicine·Lars SjöströmUNKNOWN Swedish Obese Subjects Study
May 13, 2008·The American Journal of Clinical Nutrition·Christoph GasteygerArne Astrup
Nov 7, 2008·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Rajasekhara R MummadiGagan K Sood
Aug 12, 2009·Journal of Hepatology·Alexander R MoschenHerbert Tilg
Aug 20, 2009·Gerontology·James FrithJulia L Newton
Apr 2, 2010·Healthcare Quarterly·Janine ArkinsonHeather Dawson
Nov 26, 2010·Journal of Digestive Diseases·Leon A Adams, Ariel E Feldstein
May 21, 2011·Science·Jeremiah J FaithJeffrey I Gordon
Sep 3, 2011·Science·Gary D WuJames D Lewis
Jun 13, 2012·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·A N PayneC Lacroix
Jan 1, 2007·Obesity Research & Clinical Practice·Sara WahlroosCampbell H Thompson
Jan 18, 2014·Obesity Surgery·Stephen HewittTom Mala
Jun 11, 2014·JAMA : the Journal of the American Medical Association·Lars SjöströmLena M S Carlsson
Apr 22, 2015·Current Diabetes Reports·Chiara SaponaroAmalia Gastaldelli
Mar 5, 2016·World Journal of Gastroenterology : WJG·Bérénice CharrezLionel Hebbard
Jun 18, 2016·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Adam DoyleNazia Selzner
Oct 13, 2016·CMAJ Open·Fady SalehDennis Hong

❮ Previous
Next ❯

Citations

May 3, 2018·Toxicological Sciences : an Official Journal of the Society of Toxicology·Hui LiNathan J Cherrington
Apr 19, 2018·The Journal of Endocrinology·Ashley PattonKelly D McCall
May 18, 2019·Endocrine Reviews·Matthew J WattMagdalene K Montgomery
Mar 25, 2020·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Mikiko WatanabeLucio Gnessi
Jun 3, 2021·International Journal of Molecular Sciences·Agostino Di CiaulaPiero Portincasa
Jul 13, 2019·International Journal of Surgery·A HussainS El-Hasani
Sep 4, 2021·Gastroenterology·Mohamed I Elsaid, Vinod K Rustgi
Oct 29, 2021·Frontiers in Endocrinology·Kenneth PasmansRuth C R Meex

❮ Previous
Next ❯

Related Concepts

Related Feeds

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.

Biomarkers for Diabetes

This feed focuses on the latest research on biomarkers used for monitoring disease progression in diabetes.

Related Papers

Journal of Hepatology
Mariana MachadoHelena Cortez-Pinto
Nihon rinsho. Japanese journal of clinical medicine
Keisuke OeToshiji Saibara
Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association
Steven P LarsonStephen A Harrison
© 2022 Meta ULC. All rights reserved