Non-Alcoholic Fatty Liver Disease in Overweight Children: Role of Fructose Intake and Dietary Pattern

Nutrients
Anika NierIna Bergheim

Abstract

The role of nutrition and diet in the development of non-alcoholic fatty liver disease (NAFLD) is still not fully understood. In the present study, we determined if dietary pattern and markers of intestinal permeability differ between overweight children with and without NAFLD. In addition, in a feasibility study, we assessed the effect of a moderate dietary intervention only focusing on nutrients identified to differ between groups on markers of intestinal barrier function and health status. Anthropometric data, dietary intake, metabolic parameters, and markers of inflammation, as well as of intestinal permeability, were assessed in overweight children (n = 89, aged 5⁻9) and normal-weight healthy controls (n = 36, aged 5⁻9). Sixteen children suffered from early signs of NAFLD, e.g., steatosis grade 1 as determined by ultrasound. Twelve children showing early signs of NAFLD were enrolled in the intervention study (n = 6 intervention, n = 6 control). Body mass index (BMI), BMI standard deviation score (BMI-SDS), and waist circumference were significantly higher in NAFLD children than in overweight children without NAFLD. Levels of bacterial endotoxin, lipopolysaccharide-binding protein (LBP), and proinflammatory markers like int...Continue Reading

References

Feb 1, 1970·Archives of Disease in Childhood·W A Marshall, J M Tanner
Jun 1, 1969·Archives of Disease in Childhood·W A Marshall, J M Tanner
Nov 4, 1998·Zeitschrift für Ernährungswissenschaft·W Sichert-HellertG Schöch
Oct 24, 2001·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·K McManusF Sacks
May 10, 2002·Journal of Gastroenterology and Hepatology·Paul Angulo, Keith D Lindor
Dec 24, 2003·European Journal of Pediatrics·Christian DenzerKurt Widhalm
Jun 21, 2006·Metabolism: Clinical and Experimental·Andrew K ChenR James Barnard
Dec 5, 2006·Nutrition·Kumiko ToshimitsuMorikazu Onji
Apr 9, 2008·Journal of Hepatology·Xiaosen OuyangManal F Abdelmalek
Apr 9, 2008·Journal of Hepatology·Ina BergheimStephan C Bischoff
Oct 18, 2008·Canadian Journal of Gastroenterology = Journal Canadien De Gastroenterologie·Nimer AssyMaria Grosovski
Aug 15, 2009·The Journal of Nutritional Biochemistry·Astrid Spruss, Ina Bergheim
Sep 24, 2009·The Journal of Clinical Endocrinology and Metabolism·Christian DenzerMartin Wabitsch
Dec 17, 2009·Current Opinion in Gastroenterology·Shelby Sullivan
Mar 11, 2010·European Journal of Clinical Nutrition·D R MagerE A Roberts
Mar 20, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Manal F AbdelmalekUNKNOWN Nonalcoholic Steatohepatitis Clinical Research Network
Apr 1, 2010·Journal of Inflammation·Alison L HartePhilip G McTernan
Apr 20, 2010·Journal of Pediatric Gastroenterology and Nutrition·Anna AlisiValerio Nobili
Sep 14, 2010·Pediatrics International : Official Journal of the Japan Pediatric Society·Ina B MaierIna Bergheim
Mar 23, 2011·Laboratory Investigation; a Journal of Technical Methods and Pathology·Giridhar KanuriIna Bergheim
Aug 2, 2011·The Proceedings of the Nutrition Society·Thomas Reinehr
Jun 7, 2013·International Journal of Molecular Sciences·Giridhar Kanuri, Ina Bergheim
Dec 20, 2013·Liver International : Official Journal of the International Association for the Study of the Liver·Giridhar KanuriIna Bergheim
Mar 13, 2014·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·D C L MasquioA R Dâmaso
Jun 26, 2014·Pediatric Obesity·J S SullivanS S Sundaram
Aug 7, 2014·Arab Journal of Gastroenterology : the Official Publication of the Pan-Arab Association of Gastroenterology·Yasmine M AlkassabanyEngy M El-Ghitany
Oct 10, 2015·The British Journal of Nutrition·Cheng Jun JinIna Bergheim
Nov 17, 2016·BMC Pediatrics·Deise Rosa FélixGabriela Perdomo Coral
Sep 21, 2017·Nature Reviews. Gastroenterology & Hepatology·Zobair YounossiElisabetta Bugianesi

❮ Previous
Next ❯

Citations

Sep 3, 2019·Journal of Nutritional Science and Vitaminology·Katsuhisa OmagariKoichi Tsuneyama
Mar 14, 2019·Nutrients·Jörn M Schattenberg, Ina Bergheim
Dec 12, 2020·Pediatric Obesity·Johanna K DiStefano, Gabriel Q Shaibi
Mar 3, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Yan LiZhengzhi Wu
May 20, 2021·European Journal of Clinical Nutrition·Luisa BonsembianteClaudio Maffeis
Sep 10, 2021·Scientific Reports·Anja BaumannIna Bergheim

❮ Previous
Next ❯

Methods Mentioned

BETA
ELISA
enzymatic assay

Clinical Trials Mentioned

NCT01306396

Software Mentioned

EBISpro
GraphPad
GraphPad Prism

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.