Non-alcoholic fatty liver disease in pregnancy is associated with adverse maternal and perinatal outcomes.

Journal of Hepatology
Monika SarkarNorah Terrault

Abstract

The prevalence of non-alcoholic fatty liver disease (NAFLD) is rising in young adults, with potential implications for reproductive-aged women. Whether NAFLD during pregnancy confers more serious risks for maternal or perinatal health is unclear. Using weighted discharge data from the US national inpatient sample, we evaluated temporal trends of NAFLD in pregnancies after 20 weeks gestation, and compared outcomes to pregnancies with other chronic liver diseases (CLDs) or no CLD. Study outcomes included preterm birth, postpartum hemorrhage, hypertensive complications (pre-eclampsia, eclampsia, and/or hemolysis, elevated liver enzymes, and low platelets syndrome), and maternal or fetal death. NAFLD prevalence was estimated by calendar year and temporal trends tested by linear regression. Outcomes were analyzed by logistic regression adjusted for age, race, multiple gestation, and pre-pregnancy diabetes, obesity, dyslipidemia and hypertension. Among 18,574,225 pregnancies, 5,640 had NAFLD and 115,210 had other, non-NAFLD CLD. Pregnancies with NAFLD nearly tripled from 10.5/100,000 pregnancies in 2007 to 28.9/100,000 in 2015 (p <0.001). Compared to the other groups, patients with NAFLD during pregnancy more frequently experienced g...Continue Reading

Citations

Sep 18, 2020·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Yorinari OchiaiHiromitsu Kumada
Sep 19, 2020·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Monika SarkarNorah A Terrault
Sep 1, 2020·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Kara WegermannCynthia A Moylan
Dec 16, 2020·Journal of Hepatology·Jessica Phillips, Sivanthi Senaratne
Jan 20, 2021·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Monika SarkarJennifer A Flemming
Mar 15, 2021·The Lancet. Gastroenterology & Hepatology·Swathi RajagopalMonika Sarkar
Apr 4, 2021·Journal of Hepatology·Jennifer A Flemming, Maria P Velez
Sep 23, 2020·Journal of Hepatology·Antonella MoscaAnna Alisi
Sep 12, 2021·Clinical Medicine : Journal of the Royal College of Physicians of London·Elvyna LimLucy MacKillop
Sep 23, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Begoña ZapateríaMaría Pilar Ramos-Álvarez
Dec 21, 2021·The American Journal of Gastroenterology·Annsa C HuangMonika Sarkar
Sep 18, 2021·Clinical and Molecular Hepatology·Hydar El JamalyMartin Weltman

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