Non-alcoholic fatty liver disease increases the risk of incident chronic kidney disease.

United European Gastroenterology Journal
Leonard KapsJörn M Schattenberg

Abstract

Non-alcoholic fatty liver disease (NAFLD) is a highly prevalent chronic liver disease. Its role in the development of extrahepatic co-morbidities is under investigation. The impact of NAFLD on the development of chronic kidney disease (CKD) is incompletely understood. The aim of this study was to explore the potential contribution of NAFLD on CKD in Germany. The Disease Analyzer Database covering 7.49 million cases in Germany was explored for patients diagnosed with NAFLD between 2000 and 2015 and was matched 1:1 to a cohort without NAFLD. Matching criteria included age, sex, physician, index year and co-diagnoses associated with CKD. The primary outcomes of this study were incidences of CKD and end-stage renal disease. A total of 48,057 patients with NAFLD were matched to 48,057 patients without NAFLD. Within 10 years of the index date, 17.1% of patients with NAFLD and 11.6% of patients without NAFLD were diagnosed with CKD (p < 0.001). On Cox regression analysis, NAFLD was significantly associated with the incidence of CKD (hazard ratio (HR) = 1.58, p < 0.001). This association remained significant across different age groups and subgroups such as patients with diabetes mellitus or arterial hypertension. There was no associat...Continue Reading

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Citations

Oct 11, 2020·Digestive Diseases and Sciences·Christian LabenzJörn M Schattenberg
Dec 9, 2020·Zeitschrift für Gastroenterologie·Maurice Michel, Jörn M Schattenberg
Jan 13, 2021·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Amandeep SinghNaim Alkhouri
Nov 24, 2020·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·Ruihua LiuXiao Yang
Dec 22, 2020·Frontiers in Pharmacology·Cheng PengCheng Xue Qin
Feb 19, 2021·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·Christian LabenzJörn M Schattenberg
Dec 16, 2020·Clinical and Molecular Hepatology·Karn WijarnpreechaDonghee Kim
Jun 3, 2021·Journal of Clinical Medicine·Carolina M PerdomoJavier Escalada
Jan 25, 2021·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Hannes HagströmFredrik Åberg
Jul 13, 2021·Therapeutic Advances in Chronic Disease·Xiaoyan CaiYuli Huang
Jul 22, 2021·United European Gastroenterology Journal·Christian LabenzJörn M Schattenberg

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Software Mentioned

IQVIA
Disease Analyzer
SAS

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